Results 141 to 150 of about 13,682,106 (300)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Approaches for enhancing patient-reported experience measurement with ethnically diverse communities: a rapid evidence synthesis

International Journal for Equity in Health
Background Patient-reported experience measures (PREMs) are used to drive and evaluate unit and organisational-level healthcare improvement, but also at a population level, these measures can be key indicators of healthcare quality.
Reema Harrison, Maha Pervaz Iqbal, Upma Chitkara, Corey Adams, Ashfaq Chauhan, Rebecca Mitchell, Elizabeth Manias, Megan Alston, Anne Marie Hadley   +8 more
doaj   +1 more source

Measuring Quality in Hand Surgery Using Patient Reported Experience Measures

, 2020
Objectives/Interrogation: Patient-reported experience measures are becoming an international standard for measuring quality of healthcare delivery. Studies have shown that satisfied patients are more likely to have a positive outlook on their condition, and believe that their treatment will be [for full text, please go to the a.m. URL]
Tong, PY, Cen, D, Law, R, Rajaratnam, V
openaire   +2 more sources

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Developing the Patient Experience Assessment Questionnaire for Hospital Inpatient Care in South Korea

Health Expectations
Background Measuring patient experiences has become a key initiative for improving healthcare quality worldwide. Since patient experiences are inherently shaped by sociocultural context and healthcare system structures, developing locally relevant ...
Yeongchae Song, Jung‐Eun Kim, Bon Mi Koo, Young‐Geun Choi, Un‐Na Kim, Jin Yong Lee, Min‐Woo Jo, Minsu Ock, Young Kyung Do   +8 more
doaj   +1 more source

Patient experiences with systematically-administered patient-reported outcome measures in multiple sclerosis

Multiple Sclerosis and Related Disorders
There have been limited studies on the views of persons with MS (PwMS) around the systematic use of Patient Reported Outcome Measures (PROMs). The objective of this study was to explore the perspectives of PwMS on the integration of PROMs into clinical practice as part of a randomized trial.We conducted a qualitative substudy of our previous randomized
Vincent Desbiens, Genieve Wong, Shania Liu, Nathan Y. Chu, Kaitlyn E. Watson, Penelope Smyth, Ross T. Tsuyuki   +6 more
openaire   +2 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

The Patient Experience of Cancer-Related Cachexia: Implications for Patient-Reported Outcomes Measures

Clinical Medicine Insights: Oncology
Background: Understanding the patient experience, including symptoms and impacts, of cancer-related cachexia is an important step in developing and validating patient-reported outcome measures that can support the subsequent development of new treatments.
Harrington, Magdalena, Martin, Susan, Olayinka-Amao, Oyebimpe, Fang, Jarjieh, McLeod, Euan, Jacobs, Ira   +5 more
openaire   +3 more sources

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source