Results 151 to 160 of about 2,875,336 (355)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Patient-Reported Outcome Measures after Multilevel Lumbar Total Disc Arthroplasty for the Treatment of Multilevel Degenerative Disc Disease [PDF]

, 2020
Furness, James, Hing, Wayne, McEntee, Laurence, Rathbone, Evelyne, Schram, Ben, Scott-Young, Matthew, Zotti, Mario   +6 more
core   +1 more source

Patient-reported outcome measures [PDF]

Journal of the Royal Society of Medicine, 2007
openaire   +2 more sources

Person-centered care in Uganda: analysis of responsiveness, patient satisfaction, patient-reported health outcomes, and trust among adults [PDF]

, 2022
Jocelyn Fifield, Griffith Bell, Lisa R. Hirschhorn, Simon P. S. Kibira, June‐Ho Kim, Fredrick Makumbi, Elizabeth Nabiwemba, Dan Schwarz, Fred Wabwire‐Mangen, Hannah Ratcliffe   +9 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Quality of life after idiopathic multicentric Castleman disease in China: a cross-sectional, multi-center survey of patient reported outcome and caregiver reported outcome

Orphanet Journal of Rare Diseases
The majority of multicentric Castleman disease (MCD) patients in China are of the idiopathic subtype (iMCD) with systemic manifestations. However, the impact of iMCD on life quality, mental and psychological status, social function, and caregiving burden
Jia Chen, Miao-yan Zhang, Yu-han Gao, Lu Zhang, Jian Li   +4 more
doaj   +1 more source

Presentation approaches for enhancing interpretability of patient-reported outcomes in meta-analyses: a systematic survey of Cochrane reviews [PDF]

, 2023
Linan Zeng, Liang Yao, Yuting Wang, Mi Ah Han, Anders Granholm, Fernando Kenji Nampo, Borna Tadayon Najafabadi, Xiaofeng Ni, Lingli Zhang, Tahira Devji, Gordon Guyatt   +10 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Developing Quality Metrics From Patient-reported Outcomes for Medical Rehabilitation [PDF]

, 2019
Allen W. Heinemann, Arielle Goldsmith, Ana Mišković, David Cella, Anne Deutsch, Karon F. Cook, Linda Foster, Katherine Davis   +7 more
openalex   +1 more source