Results 101 to 110 of about 1,843,947 (302)

Patient‐reported outcome measures in pediatrics: An overview of reviews

Pediatric Discovery
Patient‐reported outcome measures (PROMs) are standardized and validated self‐administered questionnaires for assessing patients' overall well‐being, disease burden, and health‐related quality of life.
Ruobing Lei, Jin Xiong, Haiyun Wang, Yuehuan Li, Janne Estill, Qiu Li, Yaolong Chen   +6 more
doaj   +1 more source

Functionality and feedback: a realist synthesis of the collation, interpretation and utilisation of patient-reported outcome measures data to improve patient care

, 2017
Background: The feedback of patient-reported outcome measures (PROMs) data is intended to support the care of individual patients and to act as a quality improvement (QI) strategy.
J. Greenhalgh, S. Dalkin, K. Gooding, E. Gibbons, Judy M. Wright, D. Meads, N. Black, J. Valderas, R. Pawson   +8 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Orthopaedic registries with patient-reported outcome measures

EFORT Open Reviews, 2019
Total joint arthroplasty is performed to decreased pain, restore function and productivity and improve quality of life. One-year implant survivorship following surgery is nearly 100%; however, self-reported satisfaction is 80% after total knee ...
I. Wilson, E. Bohm, A. Lübbeke, S. Lyman, S. Overgaard, O. Rolfson, A. W-Dahl, M. Wilkinson, M. Dunbar   +8 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Patient reported outcomes used in clinical trials and core outcome sets for individuals with genetic intellectual disability: a scoping review

Journal of Neurodevelopmental Disorders
Background The impact of genetic intellectual disability (GID) on daily life is significant. To better understand the impact of GID, it is essential to measure relevant patient reported outcomes (PROs).
Nadia Y. van Silfhout, Maud M. van Muilekom, Clara D. van Karnebeek, Joost G. Daams, Lotte Haverman, Agnies M. van Eeghen   +5 more
doaj   +1 more source

Assessing test–retest reliability of patient-reported outcome measures using intraclass correlation coefficients: recommendations for selecting and documenting the analytical formula

Quality of Life Research, 2018
PurposeThe US Food and Drug Administration (FDA) 2009 guidance for industry on patient-reported outcome (PRO) measures describes how the Agency evaluates the psychometric properties of measures intended to support medical product labeling claims.
S. Qin, L. Nelson, L. McLeod, S. Eremenco, S. Coons   +4 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source