Results 281 to 290 of about 1,479,071 (353)

BMI and its association with patient-reported outcome measures following revision hip surgery. [PDF]

Bone Jt Open
Baumber R, Mehmood A, McCulloch R, Pereira SMP, Warwick E, Hart A, Moonesinghe SR, PQIP delivery team, PQIP collaborative, PQIP delivery team and collaborative, PQIP Delivery Team, Ramani Moonesinghe S, Wagstaff D, Bedford J, Sahni A, McGuckin D, Gilhooly D, Santos C, Wilson J, Martin P, Singleton G, Edwards K, Vindrola-Padros C, Warnakulasuriya S, Dorey J, Leemans I, Martinez D, Lourtie J, Baumber R, Dorey J, Swift A, Jackson A, Belete M, Warwick E, Argent M, Brooks R, Fulop N, Brent A, Williams K, Grocott M, Mythen M, Olive D, Taylor C, Drake S, Swart M, Bougeard AM, Bedford M, Vallance A, Singh P, Vohra R, Ignacka A, Tucker O, Aresu G, Cripps M, Ellicott H, Samuel K, Chazapis M, Hunt AF, Lusby E, Durrand J, Weerasuriya S, PQIP Collaborative, Batchelor A, Snowden C, Murray D, Evans E, Vaux E, Abercrombie J, McGhie J, Dhesi J, Clark T, Crossley A, McGrath J, Digner M, Hamilton M, Hill R, Shinde S, Brett S.   +77 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Patient Reported Outcome Measurements

Journal of Pharmaceutical Research, 2015
openaire   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Postpartum well-being in hemophilia carriers and women with von Willebrand disease: insights from patient-reported outcome measures. [PDF]

Res Pract Thromb Haemost
de Vaan A, Doeff EA, Eikenboom J, Kruip MJHA, Punt MC, Coppens M, Nieuwenhuizen L, Schols SEM, Mäkelburg ABU, Heubel-Moenen FCJI, Duvekot HJ, Peters M, Middeldorp A, Bloemenkamp KWM, Schutgens REG, van Galen KPM.   +15 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Developing a Preliminary Conceptual Framework for Guidelines on Inclusion of Patient Reported-Outcome Measures (PROMs) in Clinical Quality Registries

, 2019
Rasa Ruseckaite, Maharaj AD, Karolina Krysińska, Joanne Dean, Susannah Ahern   +4 more
openalex   +1 more source

Impact of Medical Comorbidities on Respiratory-Related Patient-Reported Outcome Measures in Fibrotic Interstitial Lung Disease. [PDF]

J Clin Med
Moon JY, Beenken M, Moua T.
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source