Results 61 to 70 of about 1,333,332 (355)

Clinical evaluation of knee joint diseases

Journal of Joint Surgery and Research, 2023
Purpose: This article aimed to comprehensively introduce clinical scoring of pathological conditions of the knee. Methods: Review articles on the clinical scores of knee joints were searched. The frequency of the clinical scores used in said articles are
Kohei Nishitani, Shinichiro Nakamura, Shinichi Kuriyama   +2 more
doaj  

Patient-Reported Outcome Measures in Urethral Reconstruction [PDF]

Current Urology Reports, 2018
Treatment of anterior urethral stricture disease (USD) has shifted from endoscopic approaches to urethroplasty with significantly higher success rates among reconstructive urologists. This academic stance has led to a critical evaluation of "success" and developing disease-specific instruments to assess surgical outcomes focusing on patients ...
Baradaran, Nima, Hampson, Lindsay A, Edwards, Todd C, Voelzke, Bryan B, Breyer, Benjamin N   +4 more
openaire   +4 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Self-Reported Outcome Measures of the Impact of Injury and Illness on Athlete Performance: A Systematic Review [PDF]

, 2016
BACKGROUND: Self-reported outcome measures of athlete health, wellbeing and performance add information to that obtained from clinical measures. However valid, universally accepted outcome measures are required.
Ashley, P, Gallagher, J, Lumsden, R, Needleman, I, Sanchez, RG   +4 more
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

The importance of qualitative methods for generating patient reported outcome measures and patient reported experience measures for pre-hospital and emergency care of stroke and heart attack [PDF]

, 2012
Context: The Patient Reported Outcomes for Vascular Emergencies: Interview Study (IS-PROVE) of patients and practitioners was conducted in a large regional ambulance service in the East Midlands region of the UK from 2010-2011.
Davy, Zowie, Siriwardena, A. Niroshan, Togher, Fiona   +2 more
core  

A Retrospective Cohort Study to Assess Patient and Physician Reported Outcome Measures After Decompressive Hemicraniectomy for Malignant Middle Cerebral Artery Stroke. [PDF]

, 2017
INTRODUCTION: Decompressive hemicraniectomy for malignant middle cerebral artery (MCA) infarction is known to reduce mortality. However, there are on-going concerns in terms of the quality of life in survivors. We aimed to examine the correlation between
Budhdeo, S, Chari, A, Clark, DJ, Hutchinson, PJ, Kolias, AG, Warburton, EA   +5 more
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Measuring Patient-Reported Outcomes Adaptively: Multidimensionality Matters! [PDF]

Applied Psychological Measurement, 2017
As there is currently a marked increase in the use of both unidimensional (UCAT) and multidimensional computerized adaptive testing (MCAT) in psychological and health measurement, the main aim of the present study is to assess the incremental value of using MCAT rather than separate UCATs for each dimension.
Paap, Muirne C. S., Kroeze, Karel A., Glas, Cees A.W., Terwee, Caroline B., van der Palen, Job, Veldkamp, Bernard P   +5 more
openaire   +7 more sources