Results 61 to 70 of about 6,240,892 (301)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Patient Safety Tool Box Talks© Theme 2 Talks [PDF]
, 2013 Patient Safety Toolbox Talks© are a resource to enable short, discussions or presentations by line managers to their staff which is generally focused on one specific topic or theme which addresses in simple terms to prompt staff to practice in a safer ...
HSE Dublin North East Quality and Patient Safety
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
, 2008 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.v. 1, no. 2 (May 2008)-v. 2, no. 1 (Feb. 2009)Mode of access:
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Patient Safety Tool Box Talks© Theme 5 Talks [PDF]
, 2013 Patient Safety Toolbox Talks© are a resource to enable short, discussions or presentations by line managers to their staff which is generally focused on one specific topic or theme which addresses in simple terms to prompt staff to practice in a safer ...
HSE Dublin North East Quality and Patient Safety
core
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Patient Safety Tool Box Talks© Theme 8 Talks [PDF]
, 2013 Patient Safety Toolbox Talks© are a resource to enable short, discussions or presentations by line managers to their staff which is generally focused on one specific topic or theme which addresses in simple terms to prompt staff to practice in a safer ...
HSE Dublin North East Quality and Patient Safety
core
Enteral feeding pumps: efficacy, safety, and patient acceptability [PDF]
, 2014 Helen White, Linsey King Nutrition and Dietetic Group, School of Health and Wellbeing, Faculty Health and Social Science, Leeds Metropolitan University, Leeds, United Kingdom Abstract: Enteral feeding is a long established practice across pediatric and ...
White H, King L, White, H, King, L
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source