Results 81 to 90 of about 6,240,892 (301)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

We All Win When Patients Speak Up: A Conversation With Patient Advocate Lisa Rodebaugh; Executive Director of the Patient Safety Authority (PSA), Regina Hoffman; and PSA director of Engagement, Caitlyn Allen.

open access: yesPatient Safety, 2021
Lisa Rodebaugh: My husband, Bill, and I can rattle off our stories in two minutes or less—stories from having five children, each with varying medical and developmental needs that presented far differently from what specialists typically see.
Lisa Rodebaugh   +2 more
doaj  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Batteries Gone Bad

open access: yesPatient Safety, 2019
A battery's moment of death may come as a beep, a red warning light, or a complete surprise. If you are lucky (i.e., prepared), you have a power cord or backup battery handy.
Kim Liberatore, Barry Kohler
doaj   +1 more source

Patient Safety Alert: Air Embolism During Cardiac Ablation [PDF]

open access: yes, 2022
During a cardiac ablation procedure, the catheter irrigation fluid bag emptied and was replaced by staff. While priming the tubing, air was noted in the tube, and the catheter was immediately removed from the patient.
Bruce C Hansel, Michelle Bell
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Data Snapshot: Faces of Falls

open access: yesPatient Safety, 2019
Falls are a common and often devastating health threat for hospitalized patients, as they can cause serious injuries such as a hip fracture, and even lead to death.1 Falls in Pennsylvania continue to be one of the biggest contributors to patient harm and
Susan C. Wallace, Caitlyn Allen
doaj   +1 more source

... pharmacy annual summary [PDF]

open access: yes
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Began and ceased with 2012Includes bibliographical ...

core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Patient Safety Tool Box Talks© Brief Introduction

open access: yes, 2013
Patient Safety Toolbox Talks© are a resource to enable short, discussions or presentations by line managers to their staff which is generally focused on one specific topic or theme which addresses in simple terms to prompt staff to practice in a safer ...
HSE Dublin North East Quality and Patient Safety
core  

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