Results 91 to 100 of about 6,593,466 (305)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Patterns of errors and weaknesses in the diagnostic process: retrospective analysis of malpractice claims and adverse events from two national databases

BMJ Open Quality
Background Diagnostic errors (DEs) are a significant global patient safety issue, often associated with increased morbidity and mortality due to overlooked, delayed, or incorrect diagnoses.
Kim Lyngby Mikkelsen, Charlotte Frendved, Siri Tribler, Eva Benfeldt, Rikke Mørch Jørgensen   +4 more
doaj   +1 more source

Data Snapshot: Faces of Falls

Patient Safety, 2019
Falls are a common and often devastating health threat for hospitalized patients, as they can cause serious injuries such as a hip fracture, and even lead to death.1 Falls in Pennsylvania continue to be one of the biggest contributors to patient harm and
Susan C. Wallace, Caitlyn Allen
doaj   +1 more source

Patient Safety Tool Box Talks© Procedural Guidance for managers

, 2013
Patient Safety Toolbox Talks© are a resource to enable short, discussions or presentations by line managers to their staff which is generally focused on one specific topic or theme which addresses in simple terms to prompt staff to practice in a safer ...
HSE Dublin North East Quality and Patient Safety
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Patient Safety Alert: Serious Harm Associated With Failure to Adjust Clozapine Dosing

Patient Safety, 2023
Patient Safety Authority
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Patient Safety Tool Box Talks© Theme 3 Talks

, 2013
Patient Safety Toolbox Talks© are a resource to enable short, discussions or presentations by line managers to their staff which is generally focused on one specific topic or theme which addresses in simple terms to prompt staff to practice in a safer ...
HSE Dublin North East Quality and Patient Safety
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Patient Safety Compass - Volume 11, Issue 3

, 2021
https://scholarlycommons.baptisthealth.net/bg-bh-patient-safety-compass/1019/thumbnail ...
Baptist Health South Florida, Patient Safety
core