Results 271 to 280 of about 15,807,632 (359)

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

Recovery Time, Patient Satisfaction, and Safety of Intranasal Sedatives in Pediatric Dentistry: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Haridoss S, Shan S, Madiraju GS, Swaminathan K, Mohan R, Asiri FYI, Almugla YM, Hamidaddin MA.   +7 more
europepmc   +1 more source

Volumetric Engineered 3D Drug Reservoir Against Diabetic Implant Infection via Cuproptosis‐Like Bacterial Death and Hunger‐Triggered Maintenance of Mitochondrial Integrity

Advanced Science, EarlyView.
This study provides a volumetric engineered 3D drug reservoir to combat diabetic implant infection. Cu‐doped quantum dots induce cuproptosis‐like bacterial death via metabolic collapse, while glucose oxidase triggers hunger‐triggered mitochondrial protection in host cells.
Dize Li, Hongrui Qin, Min Jiang, Hongjiang Wei, Hongyong Zhao, Ping Tang, Guangyu Jian, Henny C van der Mei, Tao Chen   +8 more
wiley   +1 more source

Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
The aberrant adenosine metabolism leads to chemoresistance and immunosuppressive microenvironment. A versatile albumin‐polyplexes conjugated nanoparticle B‐PDEA@CPA is prepare for the codelivery of gemcitabine and siCD39. The nanoparticle releases gemcitabine‐loaded albumin upon microenvironment to achieve promoted penetration and cellular uptake ...
Hongrui Fan, Hongyi Chen, Haolin Song, Chufeng Li, Yu Wang, Zhenhao Zhao, Qin Guo, Xuwen Li, Mingxuan Liu, Tao Sun, Chen Jiang   +10 more
wiley   +1 more source

Aesthetic lower limb lengthening techniques: a systematic review of efficacy, complications, and patient satisfaction. [PDF]

J Orthop Surg Res
Giorgino R, Cornacchini J, Sillmann YM, Kostyra D, Berkane Y, Peretti GM, Mangiavini L.   +6 more
europepmc   +1 more source

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

Advanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan, Xinbo Zhao, Xuejie Han, Yukai Cao, Xuexin Jin, Ling Shi, Xin Bi, Desheng Li, Yun Zhang, Wenbo Ma, Jiahui Song, Zhenwei Pan, Zhiren Zhang, Yue Li   +13 more
wiley   +1 more source

Deep Learning‐Assisted Rapid Bacterial Classification Based on Raman Spectroscopy of Bacteria Lysed by Acoustically Driven Fiber‐Tip Vibration

Advanced Science, EarlyView.
A novel acoustofluidic lysis technique based on a vibrating fiber‐tip is integrated with Raman spectroscopy and deep learning for rapid, label‐free bacterial classification. By exposing intracellular biomolecules, this method significantly enhances spectral resolution, enabling high‐accuracy classification with a 1D‐ResNet model.
Yukai Liu, Miaomiao Ji, Xiao Ren, Zhenyong Dong, Tian Wen, Qingyue Dong, Ho‐pui Ho, Lunbiao Cui, Yanqing Lu, Guanghui Wang   +9 more
wiley   +1 more source

Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation

Advanced Science, EarlyView.
Inspired by the prolactin secretion profile under normal physiological conditions, biomimetic prolactin‐releasing microneedles are designed. Under the control of near infrared (NIR), these responsive microneedles facilitate pulsed release of prolactin to inhibit fatty liver formation.
Hongli Yin, Wenjuan Tang, Danqing Huang, JingJing Gan, Pengzi Zhang, Yuanjin Zhao, Yan Bi   +6 more
wiley   +1 more source

The quest for comfort: Exploring the effectiveness of and patient satisfaction with needleless anesthesia in dental procedures. [PDF]

J Conserv Dent Endod
Singh S, Koshy M.
europepmc   +1 more source

The Effect of Immersion Technology on the Quality of Life in Older Adults: A Systematic Review

AGING MEDICINE, EarlyView.
Immersive technologies, especially virtual reality (VR), significantly improve the quality of life for older adults by enhancing physical health, cognitive function, and psychological well‐being. These technologies can be adapted to meet individual needs, making them an effective tool for addressing the challenges of aging.
Solmaz Sohrabei, Vahideh Zolfaghari, Seyed Jafar Ehsanzadeh   +2 more
wiley   +1 more source