Results 201 to 210 of about 6,273,546 (305)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Economic Evaluation of NHS England's Type 2 Diabetes Path to Remission Pilot Scheme: Evidence From Real-World Data and Patient Simulation Modelling. [PDF]

Pharmacoecon Open
Martin A, Zabula T, Tebaldi D, Yang M, Brown T, Ells L.   +5 more
europepmc   +1 more source

Family dyads, emotional labor, and holding environments in the simulated encounter: co-constructive patient simulation as a reflective tool in child and adolescent psychiatry training. [PDF]

Child Adolesc Psychiatry Ment Health, 2023
Thomas I, Benoit L, Duvivier R, de Carvalho Filho MA, Martin A.   +4 more
europepmc   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

Learning Last Hours of Life Care Through Patient Simulation Scenario: Experiences of Medical and Nursing Undergraduate Students. [PDF]

Med Sci Educ
Bernabé SR, Garayoa LS, Martínez AU, Valcárcel AC, Moreno LA, Cortés CC, Arantzamendi M.   +6 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Effect of high-fidelity human patient simulator manikins combined with standardized patient simulation scenario on clinical thinking in pediatric nursing education. [PDF]

BMC Nurs
Hu LY, Li SQ, Zhou ZY, Wang ML, Zhou LS.
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Comparison of Physician Assistant and Medical Students' Clinical Reasoning Processes Using an Online Patient Simulation Tool to Support Clinical Reasoning (eCREST): Mixed Methods Study. [PDF]

JMIR Med Educ
Thorpe A, Kassianos AP, Plackett R, Krishnamurthy V, Kambouri MA, Sheringham J.   +5 more
europepmc   +1 more source

Simulated Patient

Igaku Kyoiku / Medical Education (Japan), 1988
openaire   +1 more source