Results 171 to 180 of about 908,385 (316)

Gender differences in the psychosocial and functional impact of obstructive sleep apnea: findings from the SHINE patient survey. [PDF]

Sleep Breath
Mallampalli M, Mendoza A, Cooksey E, Yee J, Brouwer E, Bloudek L, Wu Y, Yu KS.   +7 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

From fragmented to integrated healthcare: an imperative for rural populations

International Journal of Integrated Care, 2014
Kim Sutherland, Jean-Frederic Levesque, Katinka Moran, Jan-Willem Weenink   +3 more
doaj   +3 more sources

The Pulmonary Hypertension Global Patient Survey: Physical and Psychosocial Impacts on Health-Related Quality of Life. [PDF]

Pulm Circ
Bunclark K, Newman J, Ghani H, Munagala S, Otter E, Fischer G, Kurzyna M, Meszaros G, Stone M, Moledina S, Howard L, Gin-Sing W, Ferrari P, Beghetti M, Toshner M, Granato M, PH GPS Consortium, Pepke-Zaba J.   +17 more
europepmc   +1 more source

Improving physician–patient communication

, 2008
This chapter looks at improving physician–patient ...
Downey, Katherine, Eckler, Petya, Worsowicz, Gregory   +2 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Biomarker recall and understanding among people living with metastatic breast cancer - results from an international patient survey. [PDF]

Breast
Schumacher-Wulf E, Fallowfield L, Chidebe RCW, Durston V, Eniu A, Kaur R, Haidinger R, Pillay N, Egbase D, Han Y, Cardoso F.   +10 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Pulmonary Hypertension Global Patient Survey: Understanding the Invisible Burden of Paediatric Pulmonary Hypertension. [PDF]

Pulm Circ
Quyam S, Drumm S, Mungala S, Bunclark K, Fischer G, Otter E, Ghani H, Gin-Sing W, Howard L, Kurzyna M, Ferrari P, Macdonald L, Newman J, Stone M, Toshner M, Pepke-Zaba J, Beghetti M, Moledina S.   +17 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source