Results 101 to 110 of about 596,025 (305)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The development and validation of a conceptual definition of avoidable transitions from long‐term care to the emergency department: A mixed methods study

Health Science Reports
Background/Objectives Transitions to and from Emergency Departments (EDs) can be detrimental to long‐term care (LTC) residents and burden the healthcare system.
Greta G. Cummings, Kaitlyn Tate, Jude Spiers, Rowan El‐Bialy, Patrick McLane, Claire Su‐Yeon Park, Tatiana Penconek, Garnet Cummings, Carole A. Robinson, Robert Colin Reid, Carole A. Estabrooks, Brian H. Rowe, Carol Anderson   +12 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Redesign process of a semi-powered patient transfer device

, 2017
Intra-facility patient transfer poses substantial risks of patient falls and care-giver???s musculoskeletal injuries. Several patient lifters and aid devices have been introduced but they have not been widely used due to their bulky size and slow ...
Shin, GwanSeob, Jeongmin Park, Gwanseob Shin, Hyun-hwa Hong, Park, Jeongmin, Hong, Hyun-hwa, Kim, Eunji, Eunji Kim   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Involving the Patient and Family in the Transfer of Information at Shift Change in a Pediatric Emergency Department

Background The transfer of information at the change of shift is a critical point for patient experience during the care process. The aim of this study was to evaluate caregivers’ perceptions before and after the implementation of a multidisciplinary ...
Muñoz Cutillas, Agustín, Mora Capín, Andrea, Jové Blanco, Ana, Barrera Brito, Vanesa, Oujo Álamo, Eduardo, Vázquez López, Paula   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The new design of smart patient transfer

, 2018
Patient transfer assist devices are not mechanical devices, such as slider sheets and transfer boards that can reduce the forces or awkward postures associated with some patient handling activities.
Farah Nadhirah
core  

The incomplete infrastructure for interhospital patient transfer [PDF]

, 2012
OBJECTIVE: Interhospital transfer of critically ill patients is a common part of their care. This article sought to review the data on the current patterns of use of interhospital transfer and identify systematic barriers to optimal integration of ...
Iwashyna, Theodore J
core