Results 61 to 70 of about 548,271 (310)
A nomogramic model for predicting the left ventricular ejection fraction of STEMI patients after thrombolysis-transfer PCI [PDF]
, 2023 Shuai Liu +8 more
openalex +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Research progress on application of Early Warning Scoring System in patient transfer
Huli yanjiu, 2021 This paper summarized background，types，application status quo in patient transfer and limitations of the Early Warning Scoring System.It aimed at providing theoretical guidance for medical staff in identification and treatment of transferred patients.
ZHANG Zixian, JIN Ying
doaj
Posterior Spinal Hemi- Anaesthesia for Tendon Transfer in Patient with Foot Drop- Case Report [PDF]
, 2023 Geetanjali Singhal +2 more
openalex +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Medicina U.P.B., 2019 Objetivo: los trasladosno regulados son aquellos en los que se transfieren pacientes a instituciones prestadoras de salud (IPS) de mayor complejidad, en búsqueda de re-cursos y que, por motivos administrativos o propios del transferido, se requieren con ...
Jaime Andrés Giraldo Hoyos +3 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
COVID-19 Patient Detection Based on Fusion of Transfer Learning and Fuzzy Ensemble Models Using CXR Images [PDF]
, 2021 Chandrakanta Mahanty +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source