Results 71 to 80 of about 548,271 (310)

Altered glutamate–glutamine and amide proton transfer-weighted values in the hippocampus of patients with amnestic mild cognitive impairment: A novel combined imaging diagnostic marker [PDF]

, 2023
Xin Chen, Tao Gong, Tong Chen, Changyuan Xu, Yuchao Li, Qingxu Song, Liangjie Lin, Georg Oeltzschner, Richard A.E. Edden, Zhangyong Xia, Guangbin Wang   +10 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Outcomes of patients with acute pulmonary embolism managed in-house vs those transferred between hospitals: a retrospective observational study

Research and Practice in Thrombosis and Haemostasis
Background: Interhospital transfer (IHT) for acute pulmonary embolism (PE) is increasingly performed to improve access to advanced reperfusion therapies.
Priyanka Sridhar, Hong Yu Wang, Agostina Velo, Destiny Nguyen, Avinash Singh, Abdul Rehman, Jason Filopei, Madeline Ehrlich, Robert Lookstein, David J. Steiger   +9 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Quality of care and challenges in medical convoy transfers during Hajj season 2023: a cross-sectional study

Frontiers in Disaster and Emergency Medicine
BackgroundThe Hajj pilgrimage, a significant spiritual journey for Muslims, occurs annually in Mecca, Saudi Arabia, attracting millions of participants from diverse backgrounds worldwide. This surge in pilgrims poses substantial challenges for healthcare
Ghadah Alsaleh, Anas Khan, Lamis Alabdulatif, Jumana Alhazmi, Amira Althobaiti   +4 more
doaj   +1 more source

Infective endocarditis treated in a secondary hospital: epidemiological, clinical, microbiological characteristics and prognosis, with special reference to patients transferred to a third level hospital [PDF]

, 2021
Ana Isabel Peláez Ballesta, Elisa García Vázquez, Joaquín Gómez Gómez   +2 more
openalex   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Comparative Algorithms for Identifying and Counting Hospitalisation Episodes of Care for Coronary Heart Disease Using Administrative Data

Clinical Epidemiology
Derrick Lopez,1 Juan Lu,1,2 Frank M Sanfilippo,1 Judith M Katzenellenbogen,1 Tom Briffa,1 Lee Nedkoff1,3 1Cardiovascular Epidemiology Research Centre, School of Population and Global Health, The University of Western Australia, Crawley, Western Australia,
Lopez D, Lu J, Sanfilippo FM, Katzenellenbogen JM, Briffa T, Nedkoff L   +5 more
doaj  

Patients Residing in Rural Areas Transferred for Mechanical Thrombectomy Undergo Decreased Catheter‐Based Treatment

Stroke: Vascular and Interventional Neurology
Background Nearly one fifth of the US population resides in rural areas. Although endovascular therapy can substantially improve clinical outcomes in patients treated with large vessel occlusion acute ischemic stroke, the penetration and outcomes of this
Amanda L. Jagolino‐Cole, Deepa Dongarwar, Sushanth Aroor, Sunil A. Sheth, Anjail Sharrief, Kori S. Zachrison, Dileep Yavagal, Kaiz S. Asif   +7 more
doaj   +1 more source