Results 181 to 190 of about 27,806,140 (362)

Cytokine Dynamics in Bortezomib-Induced Peripheral Neuropathy: Challenges in Translating Preclinical Findings to Humans. [PDF]

J Peripher Nerv Syst
Cebulla N, Schirmer D, Runau E, Flamm L, Terhorst C, Jähnel L, Güse J, Giordani N, Wieser A, Schoch F, Reinle ML, Gommersbach S, Papagianni A, Zhou X, Einsele H, Reinhold AK, Rittner H, Kortüm KM, Sommer C.   +18 more
europepmc   +1 more source

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries.

Journal of the American Medical Association (JAMA), 2016
G. Bellani, J. Laffey, T. Pham, E. Fan, L. Brochard, A. Esteban, L. Gattinoni, F. V. van Haren, A. Larsson, D. McAuley, M. Ranieri, G. Rubenfeld, B. Thompson, H. Wrigge, Arthur S Slutsky, A. Pesenti   +15 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Vasopressor Use in Acute Burn Resuscitation: A Retrospective Study. [PDF]

Acta Anaesthesiol Scand
Knappskog K, Botnar K, Kleinhapl J, Song J, El Ayadi A, Onarheim H, Guttormsen AB, Golovko G, Wolf S, Almeland SK.   +9 more
europepmc   +1 more source

Long-Term Cognitive Functioning and Psychological Well-Being in Surgically Treated Patients with Low-Grade Glioma

, 2017
Fabio Campanella, Alvisa Palese, Fabio Del Missier, Renzo Moreale, Tamara Ius, Tim Shallice, Franco Fabbro, Miran Škrap   +7 more
openalex   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Safety of Vortioxetine in Patients With Depression: A Post-Marketing Surveillance Study of Intracranial Hemorrhage in a Japanese Health Insurance Claims Database. [PDF]

Neuropsychopharmacol Rep
Inoue T, Otake R, Hoshino T.
europepmc   +1 more source

Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients.

New England Journal of Medicine, 2016
M. Leon, Craig R. Smith, Michael J. Mack, Michael J. Mack, R. Makkar, L. Svensson, S. Kodali, V. Thourani, M. Tuzcu, D. C. Miller, H. Herrmann, Darshan Doshi, D. Cohen, A. Pichard, S. Kapadia, T. Dewey, V. Babaliaros, W. Szeto, Mathew R. Williams, D. Kereiakes, A. Zajarías, K. Greason, B. Whisenant, R. Hodson, J. Moses, A. Trento, David L. Brown, W. Fearon, P. Pibarot, R. Hahn, W. Jaber, W. Anderson, Maria C. Alu, J. Webb   +33 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Same disease, different outcomes: a retrospective cohort study of COVID-19-associated AKI across Brazil's dual-tiered healthcare system. [PDF]

J Bras Nefrol
Faria NP, Suassuna JHR, Sousa CAM, Freire SM, Gomes CLR.   +4 more
europepmc   +1 more source