Results 161 to 170 of about 15,003,403 (283)

IMPROVE 2025: The 3rd International Meeting on Pathway-Related Obesity: Vision & Evidence. [PDF]

Clin Obes
Argente J, van den Akker ELT, Cetiner M, Clément K, Forsythe E, Garfield A, Kühnen P, Martos-Moreno GÁ, Meeker D, Müller HL, van Santen HM, von Schnurbein J, Segrestin B, Tanaka T, Tena-Sempere M, Wabitsch M, Zorn S, Farooqi IS.   +17 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Intracerebral Glutamate and Glycerol in Severe Acute Brain Injury: Retrospective Study of Association With Neuroworsening and Outcome. [PDF]

Acta Anaesthesiol Scand
Andreasen TH, Olsen MH, Vassilieva A, Fenger AW, Lund A, Jensen HR, Forsse A, Møller K.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Management of Neuropathic Pain in Complex Regional Pain Syndrome: A Comprehensive Review. [PDF]

Pain Pract
Donati D, D'Auria L, Ricci V, Boccolari P, Tedeschi R, Tarallo L.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Acute Pain During Intensive Care: Prevalence, Predisposing Factors and Pain Trajectories. A Prospective Multicenter Observational Study. [PDF]

Acta Anaesthesiol Scand
Wlodarczyk-Abou Elseoud AE, Kalliomäki ML, Mäkinen O, Laukkanen A, Bäcklund M, Lääperi M, Hamunen K, Kuivalainen AM.   +7 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Talking With Patients: A Teaching Approach

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Liver and Spleen Stiffness as Non-Invasive Tools Assessing Liver Congestion in Patients With Budd-Chiari Syndrome. [PDF]

Liver Int
Fodor A, Thompson MA, Nicoara-Farcau O, Belmonte E, Garcia-Criado Á, Darnell A, Pérez-Campuzano V, Vizcarra P, Requejo I, Falga Á, Veléz M, Fernandez I, Sueiras A, Torres S, Gazda J, Baiges A, Shalaby S, Ojeda A, Martin DS, Procopet B, Hernández-Gea V, Turon F, García-Pagan JC.   +22 more
europepmc   +1 more source