Results 161 to 170 of about 7,965,138 (244)

Integrating Individual Placement Support in Early Psychosis Programs: A Necessary Step to Foster Return to Employment in First Episode Psychosis Patients. [PDF]

Early Interv Psychiatry
Renda M, Golay P, Spagnoli D, Bonsack C, Abrahamyan-Empson L, Mebdouhi N, Alerci L, Conus P.   +7 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Use of ctDNA in Older Women with ER+ Breast Cancer to Facilitate Surgical De-escalation: A Prospective, Hybrid-Decentralized Trial with Correlative Studies. [PDF]

Clin Cancer Res
Carleton N, Chang AC, Chen F, Puhalla SL, Foldi J, Waltermire H, Tin A, Cowher MS, Lupinacci K, Diego EJ, Sabih Q, Johnson RR, Malhotra M, Laubenthal A, Gorantla V, Balic M, Bhargava R, Joy M, Freeman T, Bridges C, Kalashnikova E, Rodriguez A, Liu MC, Oesterreich S, Lee AV, McAuliffe PF.   +25 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Hepatitis B Virus Reactivation Risk With IL-17, IL-23/IL-12, or JAK Inhibitors: A Systematic Review and Meta-Analysis. [PDF]

Liver Int
Alhalabi M, Alshiekh HA.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Neurological Teleconsultations in General Practice: A Stepped-Wedge Cluster Randomized Clinical Trial.

JAMA Neurol
Kiel S, Wainwright KL, Angermaier A, Chenot JF, Wischmann HA, Schulz RS, Filser PJ, Flöel A, Kurth T, von Podewils F.   +9 more
europepmc   +1 more source

Steatotic Liver Disease at Primary Biliary Cholangitis Diagnosis: Association With Ursodeoxycholic Acid Response and Outcomes. [PDF]

Liver Int
Del Barrio M, Sala M, Gómez J, Horta D, Hernández-Guerra M, Salcedo M, Goñi S, Ríos-León R, Herreros ÁM, González-Santiago JM, Martínez J, Quintans NC, Ampuero J, Antón MD, Fernández-de la Varga M, Escudero D, El Hajra I, Cuenca Alarcón F, Lorente S, Andrade RJ, Riveiro-Barciela M, Castello I, Vergara M, Quiñones R, Arencibía Almeida A, Blanco Sampascual S, Leal C, García-Retortillo M, Pérez-Medrano I, Fernández-Bermejo M, Morillas RM, Gómez E, Tejedor-Tejada J, Roget M, Rodríguez-Tajes S, Alonso-Peña M, Álvarez-Cancelo A, Londoño MC, Díaz-González Á.   +38 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Breast cancer prevention in patients with gBRCA-mutated ovarian cancer. [PDF]

J Cancer Res Clin Oncol
Amann N, Krückel A, Brückner L, Gocke J, Müller C, Heindl F, Hack CC, Stumpf K, Emons J, Fasching PA, Beckmann MW, Hörner M.   +11 more
europepmc   +1 more source