Results 181 to 190 of about 15,627,075 (282)

Frailty Rather Than Sonographic Muscle Measurement Predicts Outcome in Liver Cirrhosis. [PDF]

J Cachexia Sarcopenia Muscle
Kremer WM, Schwarz A, Dumont MC, Gairing SJ, Sivanathan V, Galle PR, Sprinzl MF, Schleicher EM, Labenz C.   +8 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Correction to "Temperature Dysregulation Following Intrathecal Morphine for Cesarean Delivery Patients-A Scoping Review". [PDF]

Acta Anaesthesiol Scand
europepmc   +1 more source

Can Spleen T1 Mapping Be Used as a Marker of Adenosine Response in Cardiac MRI? [PDF]

NMR Biomed
Solis-Barquero SM, Ezponda A, Aramendía-Vidaurreta V, Vidorreta M, Pascual M, Bastarrika G, Fernández-Seara MA.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Chronic diseases: 2010–2011 progress of the unit for chronic patients and evidence-based medicine of Donostia Hospital/Patologías crónicas: evolución 2010–2011 de la unidad de crónicos y medicina basada en la evidencia del Hospital Donostia

International Journal of Integrated Care, 2012
Joxe Artetxe, Kepa Aranegi, Mª Isabel Huertas, Jose Emparanza, Iñaki Dorronsoro, Elena Suquía   +5 more
doaj   +3 more sources

The Place of Therapeutic Apheresis in Severe Immune-Related Adverse Events: A Scoping Review of Literature. [PDF]

J Clin Apher
Vuillet C, Moranne O, Daubin D, Quantin X, Palassin P, Kanouni T, Maria ATJ, MonRIO network (Montpellier Réseau Immuno‐Oncologie).   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Immunological features of patients with primary Sjögren’s syndrome and patients HCV positive with sicca syndrome.

, 1996
Damato R. Immunological features of patients with primary Sjögren’s syndrome, Pegoraro I, patients HCV positive with sicca syndrome, Casatta L, Ferraccioli GF, DE VITA, Salvatore   +5 more
core   +1 more source

Cardiovascular Autonomic Neuropathy in Charcot-Marie-Tooth Disease: A Genotype-Stratified Study of PMP22 Duplication and GJB1 Mutation Carriers. [PDF]

J Peripher Nerv Syst
Prášil K, Potočková V, Nedělka T, Prášilová A, Mazanec R.   +4 more
europepmc   +1 more source