Results 61 to 70 of about 2,595,399 (242)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Receptor-like proteins: decision-makers of plant immunity

Phytopathology Research
Receptor-like proteins (RLPs) are crucial pattern-recognition receptors on the surface of plant cells, which are involved in almost all processes of the plant life cycle.
Minrui Cai, Hongqiang Yu, E Sun, Cunwu Zuo   +3 more
doaj   +1 more source

Systemic screening of Fusarium oxysporum candidate effectors reveals FoSSP17 that suppresses plant immunity and contributes to virulence

Phytopathology Research, 2023
Fusarium oxysporum f. sp. cubense (Foc) causes Fusarium wilt of banana (Musa spp.), a notorious soil-borne vascular fungal disease threatening the global banana industry. Phytopathogens secrete effectors to suppress plant immunity.
Tian Wang, Yun Xu, Yang Zhao, Xiaofei Liang, Shuang Liu, Yufang Zhang, Zhensheng Kang, Daipeng Chen, Li Zheng   +8 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

AtSNU13 modulates pre-mRNA splicing of RBOHD and ALD1 to regulate plant immunity

BMC Biology
Pre-mRNA splicing is a significant step for post-transcriptional modifications and functions in a wide range of physiological processes in plants. Human NHP2L binds to U4 snRNA during spliceosome assembly; it is involved in RNA splicing and mediates the ...
Yanke Jiang, Yingzhe Yue, Chongchong Lu, Muhammad Zunair Latif, Haifeng Liu, Zhaoxu Wang, Ziyi Yin, Yang Li, Xinhua Ding   +8 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Plant U-box E3 ligases PUB20 and PUB21 negatively regulate pattern-triggered immunity in Arabidopsis

Plant U-box proteins (PUBs) constitute a class of E3 ligases that are associated with various stress responses. Among the class IV PUBs featuring C-terminal Armadillo (ARM) repeats, PUB20 and PUB21 are closely related homologs.
Kang, S.Y., Yi, S.Y., Nekrasov, V., Ichimura, K., Shirasu, K.   +4 more
core   +1 more source

A brief overview on early events of Xa21 mediated pattern triggered immunity [PDF]

, 2019
In plant associated pattern-triggered immunity (PTI), pattern-recognition receptors (PRRs) play crucial role in the mechanism of first line of defense against pathogenic invasion.
Abu Naser, M., Hamdan, Salehhuddin, Mubassir, M. H. M., Abdul Wahab, Mohd. Firdaus   +3 more
core   +1 more source

Early molecular events in PAMP-triggered immunity

, 2009
In plant innate immunity, the first line of microbial recognition leading to active defence responses relies on the perception of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs).
Zipfel, Cyril; https://orcid.org/, Zipfel, Cyril   +1 more
core   +1 more source