Results 81 to 90 of about 122,748 (264)
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Pattern Avoidance and the Fundamental Bijection
The fundamental bijection is a bijection $\theta:\mathcal{S}_n\to\mathcal{S}_n$ in which one uses the standard cycle form of one permutation to obtain another permutation in one-line form. In this paper, we enumerate the set of permutations $\pi\in\mathcal{S}_n$ that avoids a pattern $\sigma\in\mathcal{S}_3$, whose image $\theta(\pi)$ also avoids ...
Kassie Archer, Robert P. Laudone
openaire +2 more sources
The 1-box pattern on pattern avoiding permutations
This paper is continuation of the study of the 1-box pattern in permutations introduced by the authors in \cite{kitrem4}. We derive a two-variable generating function for the distribution of this pattern on 132-avoiding permutations, and then study some of its coefficients providing a link to the Fibonacci numbers.
Kitaev, Sergey, Remmel, Jeffrey
openaire +5 more sources
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Patterns in Random Permutations Avoiding the Pattern 132 [PDF]
We consider a random permutation drawn from the set of 132-avoiding permutations of lengthnand show that the number of occurrences of another pattern σ has a limit distribution, after scaling bynλ(σ)/2, where λ(σ) is the length of σ plus the number of descents.
openaire +3 more sources
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source

