Results 191 to 200 of about 4,090,602 (302)

Effects of Meadow Connectivity on Plant Diversity in China's Poyang Lake: New Perspective of Effective Biodiversity Conservation. [PDF]

Ecol Evol
Zhang C, Chen W, Liu Q.
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Molecular Systematics and Distribution Pattern Evolution of <i>Triplophysa</i> Species in China: A Comparison of Widespread and Narrow-Range Taxa. [PDF]

Biology (Basel)
Chen Y, Wang M, Wang Z, Chen X, Li S, Yang C, Wang D, Duan X, Tian H, Gu Q.   +9 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Microbiome network remodeling is associated with soil lipid metabolism in safflower under different cropping system-location combinations: an omics-based dissection. [PDF]

Front Microbiol
Yang Y, Jia W, Xie J, Qiu J, Li C, He C, Luo M, Zhao L, Wang Y.   +8 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Development of Genome-Derived InDel Markers and Genetic Diversity Analysis of <i>Caragana acanthophylla</i> in Xinjiang, China. [PDF]

Plants (Basel)
Yao Y, Yu Z, Bi H, Du M, Abudouwaili A, Gong S, Huang J.   +6 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Correction to: The trichome pattern diversity of Cardamine shares genetic mechanisms with Arabidopsis but differs in environmental drivers. [PDF]

Plant Physiol
europepmc   +1 more source

Population and Component Community Descriptors of Monopisthocotyla Parasitizing Triportheus spp. (Actinopterygii: Triportheidae) in the Tocantins-Araguaia River Basin, Brazil. [PDF]

Acta Parasitol
Saraiva DJ, da Costa AP, Viana DC, Nogueira RMS, Cohen SC.   +4 more
europepmc   +1 more source