Results 61 to 70 of about 454,016 (235)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Characterisation of wideband code division multiple access uplink transmit power for typical mobile usage patterns

IET Microwaves, Antennas & Propagation, 2011
With the ever-increasing demand for higher data rates and longer talk times, designing low-power RF front ends in wideband code division multiple access (WCDMA) mobile handsets is an important task. However, the power efficiency of current WCDMA RF front ends, particularly power amplifiers, is very low over the range of typical output power levels ...
J.H. Lee, A.B. Raju, R.M. Buehrer
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Analysis and suggestion of future 5G directions

Dianxin kexue, 2016
Firstly,the global research progress of 5G was briefly introduced,and the requirements and challenges of 5G were analyzed.The understanding and views on 5G were shared,and 5G was pointed out as an internet of things generation,a telecom IT generation ...
Shanzhi CHEN
doaj   +2 more sources

Performance Analysis of Dynamic Switching Method for Signal Relay Protocols for Cooperative PDMA Networks over Nakagami-m Fading Channels

Telecom
This study investigates a dynamic switching method for signal relay protocols in Cooperative Pattern Division Multiple Access (Co-PDMA) networks. The proposed approach aims to fully utilize the advantages of signal relays in fading-prone environment ...
Wanwei Tang, Qingwang Ren, Lixia Wang, Zedai Wang   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Research on Attack Construction and Intrusion Detection Methods for TDMA Wireless Sensor Networks [PDF]

Jisuanji gongcheng
The open nature of wireless media poses a challenge for information security. The Time Division Multiple Access (TDMA) protocol is a predominant protocol tailored for time-sensitive industrial applications.
WEN Minchu, LIANG Wei, ZHANG Jialin
doaj   +1 more source