Results 111 to 120 of about 2,397,910 (315)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Reappraising the SNARC effect in a polarity correspondence perspective

, 2023
reservedWe conducted two experiments two shed light on some neglected aspects of the spatial-numerical association of response codes (SNARC) effect. Eighty participants separately performed the explicit (magnitude comparison) and the implicit (parity ...
YING, QILU
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Application of pattern search method to power system valve-point economic load dispatch

, 2007
Direct search (DS) methods are evolutionary algorithms used to solve constrained optimization problems. DS methods do not require any information about the gradient of the objective function at hand, while searching for an optimum solution.
AL-Othman, A.K., Sykulski, J.K., Al-Sumait, J.S.   +2 more
core  

effect of staffing pattern on software project: an empirical analysis

, 2009
Univ SE Calif, Ctr Syst & Software Engn, ABB, Microsoft Res, IEEE, ACMSIGSOFT, N Carolina State Univ Comp SciResource allocation in software development is important and many methods have been proposed. Related empirical research is yet scarce
Fei Dong, Wang Qing, Ye Yang, Yang Ye, Li Juan, Li Mingshu, Juan Li, Mingshu Li, Qing Wang, Dong Fei   +9 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Associations between accelerometer-measured physical activity and sedentary behaviour with physical function among older women: a cross-sectional study

BMC Public Health
Background This study aimed to investigate the relationships between accelerometer-measured physical activity (PA) and sedentary behaviour (SB) with physical function (PF) among older Chinese women in the community.
Yanyu Lu, Qingqian Li, Wenbo Wang, Litao Du, Qiang He, Si Chen, Xianliang Zhang, Yang Pan   +7 more
doaj   +1 more source

Application of Pattern Search Method to Power System Economic Load Dispatch

, 2007
Direct Search (DS) methods are evolutionary algorithms used to solve constrained optimization problems. DS methods do not require information about the gradient of the objective function while searching for an optimum solution.
Alsumait, J.S., Alothman, A.K., Sykulski, J.K.   +2 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source