Results 91 to 100 of about 4,604 (260)

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Perceived Discomfort Glare from an Adaptive Driving Beam Headlight system Compared with Three Low Beam Lighting Configurations

, 2015
Adaptive driving beams (ADB) avoid glare for approaching or leading drivers but otherwise provide high beam lighting. Audi's implementation uses a matrix of LED units to deactivate individual LEDs when it detects leading or approaching vehicles.
Reagan, Ian J., Brumbelow, Matthew L.
core   +1 more source

Data_Sheet_5_Edges and gradients in lightness illusions: Role of optical veiling glare.zip

, 2022
Lightness Illusions (Contrast, Assimilation, and Natural Scenes with Edges and Gradients) show that appearances do not correlate with the light sent from the scene to the eye.
Vassilios Vonikakis (14265158), John J. McCann (14265155), Alessandro Rizzi (4419730)   +2 more
core   +1 more source

Spatiotemporal Control of Formation of Dynamic Protein Fiber Assemblies via Photophysical Effects of a Focused Laser Beam

Advanced Science, EarlyView.
Tightly focused laser irradiation can accumulate tubulin proteins at/around the laser focus, which leads to the formation of highly ordered microtubule assemblies. The assemblies can exhibit various dynamic behaviors such as radial motion, bundling, and flagella‐like rotation with motor protein and chemical energy, highlighting as a unique tool for ...
Hiroshi Y. Yoshikawa, Ren Shirata, Takuya Takeshige, Riki Yoshida, Fumika Kiryu, Kei Takano, Shuma Matsumoto, Reiji Kawanami, Natsumi Sawada, Chi‐Shiun Wu, Yang‐Hsin Shih, Hiromasa Niinomi, Takahisa Matsuzaki, Seiichiro Nakabayashi, Tomoaki Matsuura, Teruki Sugiyama, Ryuzo Kawamura   +16 more
wiley   +1 more source

Brightness for different surround conditions: The effect of transient glare [PDF]

, 2006
We measured the effect of a transient glare source on the perceived brightness of a standard luminance (Lstd) patch (0.5 cd/m2) as a function of the surround luminance (Ls).
Issolio, Luis Alberto, Colombo, Elisa Margarita, Elisa M. Colombo, Luis Issolio   +3 more
core   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

Multi-channel freeform optics for glare-free lighting

, 2019
Glare and visual discomfort are important factors that should be taken into account in illumination design. Conventional freeform optics offer perfect control over the outgoing intensity distribution, but few control over the near-field luminance ...
Desnijder, Karel, Ryckaert, Wouter, Meuret, Youri, Youri Meuret, Wouter Ryckaert, Hanselaer, Peter, Karel Desnijder, Peter Hanselaer   +7 more
core   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Why do words jump? An exploration of visually symptomatic readers

British and Irish Orthoptic Journal, 2012
Aim:  To provide an insight into the current issues in assessing visually symptomatic readers and the role of the orthoptist in the management of these patients. Methods:  A literature-based review was undertaken to investigate the assessment of patients
Nadia Northway
doaj   +1 more source