Results 71 to 80 of about 4,604 (260)

Pattern glare sensitivity distinguishes subclinical autism and schizotypy

, 2023
Schizophrenia and autism spectrum disorder are distinct neurodevelopmental disorders sharing clinically relevant behaviors. However, early sensory responses show divergent responses.
Torrens, Wendy Alfonso
core  

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study

Frontiers in Neuroscience
IntroductionAltered subjective visual sensitivity manifests as feelings of discomfort or overload elicited by intense and irritative visual stimuli.
Lenka Jurkovičová, Lenka Jurkovičová, Julie Páleník, Petr Kudlička, Petr Kudlička, Lenka Pezlar, Alexandra Ružičková, Vojtěch Juřík, Vojtěch Juřík, Radek Mareček, Radek Mareček, Robert Roman, Robert Roman, Jason J. Braithwaite, Kristian Sandberg, Jamie Near, Milan Brázdil, Milan Brázdil   +17 more
doaj   +1 more source

Algae and building façade revisited. A study of façade system for infill design

Journal of Architecture and Urbanism, 2017
Buildings account for around 30 percent of the world’s total energy consumption and a similar percentage of the world’s greenhouse gas emissions the main cause of climate change.
Widjaja Martokusumo, M. Donny Koerniawan, Heru W. Poerbo, Nissa A. Ardiani, Susan H. Krisanti   +4 more
doaj   +1 more source

Integration of Bio-Inspired Adaptive Systems for Optimizing Daylight Performance and Glare Control [PDF]

This study explores the integration of bio-inspired adaptive strategies by combining a kinetic façade with electrochromic glazing to optimize daylight performance and glare control.
Hosseini, Morteza; id_orcid, Azmoodeh, Maryam, Talaei Kamalabadi, Soroush   +2 more
core   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Investigation on Mixed Reflection Behavior of Cool Pavement Coating and Its Impact on Safety of Road Light Environment

Engineering
Due to low reflectance (5%–10%) of black asphalt pavement, most of the incident solar radiation (295–2500 nm) is absorbed and stored. This results in the high temperature (even exceeding 70 °C in summer) of the pavement surface, which leads to pavement ...
Hui Li, Ning Xie, Xue Zhang, Lijun Sun, John T. Harvey, Lei Wang   +5 more
doaj   +1 more source

Design of LED Street Lighting Adapted for Free-Form Roads

IEEE Photonics Journal, 2017
Street lighting, which is one of the main players in energy waste and light pollution at night, still faces the challenge of efficient lighting of roadways with curved and twisted shapes.
Ching-Cherng Sun, Xuan-Hao Lee, Ivan Moreno, Chen-Hao Lee, Yeh-Wei Yu, Tsung-Hsun Yang, Te-Yuan Chung   +6 more
doaj   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source