Results 81 to 90 of about 2,105,435 (297)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Pattern Identification - A Foundation for Research in the Emphasis of Design Patterns in Systems Engineering and Knowledge Capture [PDF]

Pattern Language describes the morphology and functionality of a system in the absence of design particulars. Harnessing this capability will provide the Systems Engineering discipline a means of managing the development of increasingly complex systems ...
Russell, Samuel P.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Formalization of a language for the construction of design patterns for learning

Knowledge Management & E-Learning: An International Journal
Design patterns for learning are about articulating, testing and sharing the principles of problem solving in the educational context. In this way, multiple patterns are developed to solve common problems, described in various pattern language formats ...
Rubén Buitrago, Jesús Salinas, Oscar Boude   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Secure Auditable Remote Registry Pattern for IoT Systems

Future Internet
In software engineering, pattern papers serve the purpose of providing a description of a generalized, reusable solution to recurring design problems, based on practical experience and established best practices.
Antonio Maña, Francisco J. Jaime, Lucía Gutiérrez   +2 more
doaj   +1 more source

Computable decision making on the reals and other spaces via partiality and nondeterminism

, 2018
Though many safety-critical software systems use floating point to represent real-world input and output, programmers usually have idealized versions in mind that compute with real numbers.
Anand Abhishek, Bauer Andrej, Palmgren Erik, Taylor Paul, Vickers Steven, Vickers Steven, Vickers Steven   +6 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Attitude, Aptitude, Routines, Pattern, Dan Simple Codes Dalam Pemerolehan Bahasa

Al-Adabiya: Jurnal Kebudayaan dan Keagamaan, 2018
In the study of language, which required a learner not just aptitude (language intelligence) but the main thing is more attitude are accompanied by a strong motivation and purpose that would make a learner managed to learn the language.
Rizki Amalia Sholihah
doaj   +1 more source