Results 51 to 60 of about 284,765 (244)

Etkileşimli Hikâye Anlatma Sistemlerinde Oyuncu Profilleri: Örnek C++ Örüntü Tanıma Profil Çıkartıcı

Online Academic Journal of Information Technology, 2015
Oyuncu profili çıkartma bilgisayar oyunları ile ilgili popüler bir araştırma sahasıdır ama Etkileşimli Hikaye Anlatma Sistemleri için çok önemlidir. Bu çalışmada amacımız: 1 oyuncu eylemlerini sürekli gözlemleyerek gerçek zamanlı profiller çıkartmak ...
Gökhan Şahin, Barbaros Bostan
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Matching of lateral cephalograms by means of similarity coefficients

Australasian Orthodontic Journal, 1986
This was a pilot study to establish the possible applications of taxonomic methods (taxonomy = study of the general principles of classification) to the identification of individuals.
Seliga Michelle E., Freer Terence J., Basford Kay E.   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Efficient Layout Pattern Matching Based on Augmented Vertex Hashing

Applied Sciences
Pattern matching is a key technique in the physical verification of integrated circuit designs and is widely used in lithographic hotspot detection. Existing pattern-matching algorithms face challenges in effectiveness and robustness, especially when ...
Zhirui Niu, Zhaohui Qin, Yihang Hu, Lan Chen   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Voltage Sags Matching to Locate Faults for Underground Distribution Networks

Advances in Electrical and Computer Engineering, 2011
A voltage sags matching to locate a fault for underground distribution network is presented in this paper. Firstly the method identifies the faulted section by matching a voltage sags measured at the primary substation during a fault with pre-developed ...
BAKAR, A. H. A., MOHAMAD, H., MOKHLIS, H., LI, H.   +3 more
doaj   +1 more source