Results 201 to 210 of about 110,266 (316)

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

open access: yesAdvanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li   +8 more
wiley   +1 more source

Mining frequent itemsets a perspective from operations research

open access: yes
Many papers on frequent itemsets have been published. Besides somecontests in this field were held. In the majority of the papers the focus ison speed. Ad hoc algorithms and datastructures were introduced.
Kosters, W.A., Pijls, W.H.L.M.
core  

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang   +9 more
wiley   +1 more source

Sliding window based rare partial periodic pattern mining algorithms over temporal data streams. [PDF]

open access: yesFront Big Data
Upadhya KJ   +7 more
europepmc   +1 more source

Clustering and Aggregating Clues of Trajectories for Trajectory Pattern Mining

open access: yes, 2016
In this paper, we propose a new trajectory pattern mining framework, namely Clustering and Aggregating Clues of Trajectories (CACT), for discovering trajectory routes that represent the frequent movement behaviors of a user.
Hung, Chih-Chieh;Peng, Wen-Chih;Lee, Wang-Chien
core  

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

open access: yesAdvanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng   +18 more
wiley   +1 more source

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