Results 91 to 100 of about 46,840 (304)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Frontiers in Neuroscience, 2014 Knowledge of how executive functions relate to preferred hearing aid (HA) processing is sparse and seemingly inconsistent with related knowledge for speech recognition outcomes. This study thus aimed to find out if (1) performance on a measure of reading
Tobias eNeher
doaj +1 more source
Feature selection methods for hidden Markov model-based speech recognition
, 1996 In the paper three different feature selection methods applicable to speech recognition are presented and discussed. Widely known approaches, like the principal component analysis, discriminant feature analysis and sequential search methods, have been ...
Nouza, Jan, J. Nouza
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The speech signal segmentation algorithm using pitch synchronous analysis
Open Computer Science, 2017 Parameterization of the speech signal using the algorithms of analysis synchronized with the pitch frequency is discussed. Speech parameterization is performed by the average number of zero transitions function and the signal energy function ...
Amirgaliyev Yedilkhan +2 more
doaj +1 more source
Feature selection for emotion recognition in speech: a comparative study of filter and wrapper methods [PDF]
PeerJ Computer ScienceFeature selection is essential for enhancing the performance and reducing the complexity of speech emotion recognition models. This article evaluates various feature selection methods, including correlation-based (CB), mutual information (MI), and ...
Alaa Altheneyan, Aseel Alhadlaq
doaj +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Alaryngeal Speech Enhancement Using Pattern Recognition Techniques
IEICE Transactions on Information and Systems, 2005 An alaryngeal speech enhancement system is proposed to improve the intelligibility and quality of speech signals generated by an artificial larynx transducer (ALT). Proposed system identifies the voiced segments of alaryngeal speech signal, by using pattern recognition methods, and replaces these by their equivalent voiced segments of normal speech ...
Gualberto Aguilar-Torres +2 more
openaire +1 more source