Results 61 to 70 of about 487,572 (291)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Periodically driven circulation near the shore of a lake [PDF]
, 2013 Solutions are found for a linear model of the circulation near the shore of a lake that is subject to two diurnal forcing mechanisms. The first is the day/night heating/cooling induced horizontal pressure gradient.
Farrow, D.E.
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Assessing Time Series Reversibility through Permutation Patterns
Entropy, 2018 Time irreversibility, i.e., the lack of invariance of the statistical properties of a system under time reversal, is a fundamental property of all systems operating out of equilibrium. Time reversal symmetry is associated with important statistical and physical properties and is related to the predictability of the system generating the time series ...
Massimiliano Zanin +3 more
openaire +5 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Tool path design for cube-machining test to minimize influence of Z-axis reversal error motion
Journal of Advanced Mechanical Design, Systems, and ManufacturingCube-machining test is a possible method for evaluating the accuracy of five-axis machining centers. Although the geometric errors of rotary axes can be evaluated by measuring the height and inclination errors of the machined surfaces, other error ...
Ryuta SATO +2 more
doaj +1 more source
On the fine structure of the quiet solar \Ca II K atmosphere [PDF]
, 2006 We investigate the morphological, dynamical, and evolutionary properties of the internetwork and network fine structure of the quiet sun at disk centre.
Schmidt, Wolfgang +3 more
core +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
PIEZO1 and the mechanism of the long circulatory longevity of human red blood cells.
PLoS Computational Biology, 2021 Human red blood cells (RBCs) have a circulatory lifespan of about four months. Under constant oxidative and mechanical stress, but devoid of organelles and deprived of biosynthetic capacity for protein renewal, RBCs undergo substantial homeostatic ...
Simon Rogers, Virgilio L Lew
doaj +1 more source