Results 121 to 130 of about 5,167,279 (311)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
MathematicsThis work presents a comprehensive study on formulations for the radiation pattern design of antenna arrays through convex optimization techniques, with a focus on linear, quadratic, and second-order cone programming. The proposed approaches heavily rely
Álvaro F. Vaquero, Juan Córcoles
doaj +1 more source
, 1917 Pattern No. 3721: Dress with double collar, and sleeves that are "gathered to straight cuffs rolled back at the wrists and faced." Both the collars and cuff facings are of a contrasting material. Neckline is fastened with two button closures. Wide girdle
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 1919 Pattern No. 4788: Shirtwaist with a round neckline, girdle that ties in the back, and "transparent modesty gathered by a ribbon." Neckline and short sleeves trimmed with metal bead fringe.
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Low-Complexity Gradient-Based Algorithm for Phase-Only Pattern Synthesis
IEEE AccessThis study developed a gradient-based algorithm to synthesize arbitrary power patterns with only element phases. This algorithm does not rely on any general-purpose nonlinear solver and requires only a matrix computation toolbox; thus, the algorithm is ...
Yao-Wen Hsu
doaj +1 more source
, 1917 Pattern No. 3805: Shirtwaist with a rolled collar faced in wide lace and a square-necked vest with wide lace along the upper half. Sleeves are "cut with a shaped cap to which is shirred the lower section of the sleeve, which is finished by a tight ...
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Coat-frock with waistcoat, 1919
, 1919 Pattern No. 4780: Waistcoat is trimmed along the edges with braid and down the center with a row of small buttons. Lower edge of the collared, belted blouse "turns up to form a deep cuff which is held in place at the center back with three buttons." Bell-
Vogue Pattern Service
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