Results 121 to 130 of about 2,773,097 (263)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Chitosan Oligosaccharides--Triggered Innate Immunity Contributes to Oilseed Rape Resistance against Sclerotinia Sclerotiorum

, 2013
Chitosan Oligosaccharides--Triggered Innate Immunity Contributes to Oilseed Rape Resistance against Sclerotinia ...
尹恒, 卢航, 杜昱光, 李艳, 赵小明, 张洪艳, 王文霞, Grevsen K   +7 more
core  

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Functional analysis of RALF peptides in soybean immunity and disease resistance

Phytopathology Research
Plant cell-surface-localized pattern-recognition receptors (PRRs) recognize conserved microbial patterns to activate pattern-triggered immunity (PTI), which confers mild and broad-spectrum resistance to most microbes.
Weijie Wang, Zhuoyuan He, Dongmei Wang, Guangyuan Xu, Jun Yang, Xianzhong Feng, Xiangxiu Liang, Daolong Dou, Rubin Chen   +8 more
doaj   +1 more source

COP9 Signalosome’s Role in Plant Defense Mechanisms

Plants
The COP9 signalosome (CSN) is a highly conserved eukaryotic protein complex that plays a crucial role in plant growth, development, and stress responses by modulating the ubiquitination pathway.
Zihua Lu, Chao Li, Kelin Deng, Cong Han, Zhihui Shan, Shuilian Chen, Hongli Yang, Yuanxiao Yang, Haifeng Chen, Qingnan Hao   +9 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Advances of Peptides for Plant Immunity

Plants
Plant peptides, as key signaling molecules, play pivotal roles in plant growth, development, and stress responses. This review focuses on research progress in plant peptides involved in plant immunity, providing a detailed classification of immunity ...
Minghao Liu, Guangzhong Zhang, Suikang Wang, Quan Wang   +3 more
doaj   +1 more source

Table_1_The Lamin-Like LITTLE NUCLEI 1 (LINC1) Regulates Pattern-Triggered Immunity and Jasmonic Acid Signaling.xlsx

, 2020
Pathogen-associated molecular pattern (PAMP) recognition occurs by plasma membrane located receptors that induce among other processes nuclear gene expression.
Kiruthiga Mariappan (3864430), Marilia Almeida-Trapp (8273109), Mai Jarad (8273106), Naganand Rayapuram (1826515), Michael Florian Mette (8273112), Heribert Hirt (30710), Axel Mithöfer (699485)   +6 more
core   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source