Results 1 to 10 of about 30,454 (200)
Mechanism of PAVA-induced toxicity and inflammation in a cocultured skin cell model [PDF]
Frontiers in PharmacologyBackgroundPelargonic acid vanillyl amide (PAVA), a stable synthetic analog of capsaicin, exhibits potential for therapeutic applications; however, it may present cytotoxic and pro-inflammatory risks.
Yunyang Song +13 more
exaly +4 more sources
Bayesian Ordered Lattice Design for Phase I Clinical Trials. [PDF]
Stat MedABSTRACT We develop a new framework specifically for early Phase I clinical trials called Bayesian Ordered Lattice Design (BOLD). This study is motivated by two key factors. First, Phase I clinical trials typically involve relatively small sample sizes, which can make the use of prior information on dose‐limiting toxicity (DLT) rates highly significant.
Wang GM, Tatsuoka C.
europepmc +2 more sources
Improving Maximum Tolerated Dose Selection in Model-Assisted Designs for Phase I Trials Through Bayesian Dose-Response Model. [PDF]
Pharm StatABSTRACT Model‐assisted designs have garnered significant attention in recent years due to their high accuracy in identifying the maximum tolerated dose (MTD) and their operational simplicity. To identify the MTD, they employ estimated dose limiting toxicity (DLT) probabilities via isotonic regression with pool‐adjacent violators algorithm (PAVA) after
Wakayama R, Momozaki T, Ando S.
europepmc +2 more sources
Structure-guided optimization of SLY1 expression and purification in Escherichia coli. [PDF]
Protein SciAbstract The SCFSLY1 ubiquitin ligase complex is a key regulator of gibberellin signaling, mediating the degradation of DELLA proteins through targeted ubiquitination. To enable detailed biochemical and structural studies of this complex, efficient recombinant production of SLY1 and its adaptor ASK1 is essential.
Jmii S +4 more
europepmc +2 more sources
Synthesis, characterization and irritant effects of nonivamide irritant riot control agent based on ionic liquids [PDF]
Frontiers in ChemistryActive Pharmaceutical Ingredients-Ionic liquids (API-ILs) can increase drug solubility and bioavailability of solid drugs without changing the structure of drug molecules.
Weiting Ma +6 more
doaj +2 more sources
Revista de la Facultad de Medicina, 1950 Con inmensa pesadumbre escribo estas líneas, para añorar al compañero de profesorado doctor Carlos M. Pava: quien por más de quince años me acompaño en la Cátedra de Histología, luchando por unos mismos ideales.
Luis Daniel Convers
doaj +2 more sources
پیامد باکتریهای باسیلوس در آزادسازی فسفر از پسماند جامد کارخانه روغنکشی در یک خاک آهکی [PDF]
مجله آب و خاک, 2020 پسماندها دارای مواد آلی بالا و عناصر غذایی از جمله فسفر هستند. این پژوهش با هدف بررسی فسفر قابل دسترس خاک پس از افزودن پسماند جامد کارخانه روغنکشی به خاک انجام شد. باکتری باسیلوس بومی با توان انحلال فسفر جداسازی شد. خاک با سطوح مختلف پسماند (2 و 4 درصد)
الهه هاشم پور +3 more
doaj +1 more source
Monotone Regression: A Simple and Fast O(n) PAVA Implementation
Journal of Statistical Software, 2022 Efficient coding and improvements in the execution order of the up-and-down-blocks algorithm for monotone or isotonic regression leads to a significant increase in speed as well as a short and simple O(n) implementation.
Frank M. T. A. Busing
doaj +1 more source
Capsaicinoid nonivamide improves nonalcoholic fatty liver disease in rats fed a high-fat diet
Journal of Pharmacological Sciences, 2020 Nonalcoholic fatty liver disease (NAFLD) is a chronic disease that causes morbidity associated with metabolic syndrome. NAFLD is a worldwide problem and represents a major cause of liver injury, which can lead to liver cell death.
Naruemon Wikan +6 more
doaj +1 more source
Revista Mexicana de Biodiversidad, 2023 En este estudio analizamos los patrones espaciales y temporales de la cobertura y uso del suelo de la Reserva de la Biosfera Selva El Ocote (REBISO) y sus impactos en la conectividad funcional del paisaje de acuerdo con 2 especies indicadoras, la pava ...
Maria Consuelo Escobar-Ocampo +3 more
doaj +1 more source