Results 11 to 20 of about 1,668 (172)

Bayesian Ordered Lattice Design for Phase I Clinical Trials. [PDF]

Stat Med
ABSTRACT We develop a new framework specifically for early Phase I clinical trials called Bayesian Ordered Lattice Design (BOLD). This study is motivated by two key factors. First, Phase I clinical trials typically involve relatively small sample sizes, which can make the use of prior information on dose‐limiting toxicity (DLT) rates highly significant.
Wang GM, Tatsuoka C.
europepmc   +2 more sources

Improving Maximum Tolerated Dose Selection in Model-Assisted Designs for Phase I Trials Through Bayesian Dose-Response Model. [PDF]

Pharm Stat
ABSTRACT Model‐assisted designs have garnered significant attention in recent years due to their high accuracy in identifying the maximum tolerated dose (MTD) and their operational simplicity. To identify the MTD, they employ estimated dose limiting toxicity (DLT) probabilities via isotonic regression with pool‐adjacent violators algorithm (PAVA) after
Wakayama R, Momozaki T, Ando S.
europepmc   +2 more sources

Structure-guided optimization of SLY1 expression and purification in Escherichia coli. [PDF]

Protein Sci
Abstract The SCFSLY1 ubiquitin ligase complex is a key regulator of gibberellin signaling, mediating the degradation of DELLA proteins through targeted ubiquitination. To enable detailed biochemical and structural studies of this complex, efficient recombinant production of SLY1 and its adaptor ASK1 is essential.
Jmii S, Bouard W, Rochas M, Dragon F, Cappadocia L.   +4 more
europepmc   +2 more sources

Fenología de algunas especies que son alimento para la pava aliblanca Penélope albipennis

Revista Peruana de Biología, 2008
En la Reserva Ecológica Privada Chaparrí, Chongoyape (Lambayeque) se evaluó la fenología (desarrollo vegetativo, floración y fructificación) de 17 especies vegetales que alimentan a la pava aliblanca (Penélope albipennis Taczanowski).
Joaquín R. Martos, Mariella Scarpati, Consuelo Rojas, Guillermo E. Delgado   +3 more
doaj   +1 more source

PavA of Streptococcus pneumoniae Modulates Adherence, Invasion, and Meningeal Inflammation [PDF]

Infection and Immunity, 2005
ABSTRACT Pneumococcal adherence and virulence factor A (PavA) is displayed to the cell outer surface of Streptococcus pneumoniae and mediates pneumococcal binding to immobilized fibronectin. PavA, which lacks a typical gram-positive signal sequence and cell surface anchorage
Pracht, D, Elm, C, Gerber, J, Bergmann, S, Rohde, M, Seiler, M, Kim, KS, Jenkinson, HF, Nau, R, Hammerschmidt, S   +9 more
openaire   +3 more sources

Treating thrombotic prosthetic arteriovenous access with cross-balloon occlusive thrombolysis and angioplasty

Asian Journal of Surgery, 2012
Objective: Clot embolism remains a concern due to flushing of clot and thrombolytic agent centrally in the process of percutaneous pharmacomechanical thrombolysis (PMT) for a thrombosed prosthetic arteriovenous access (PAVA), which might be reduced by a ...
Shen Sun, Heng-Wen Chou, Jer-Shen Chen, Chih-Yang Chan   +3 more
doaj   +1 more source

Galeopsomyia pava Hansson & Hanson 2023, sp.nov.

, 2023
Galeopsomyia pava Hansson sp.nov. (Figs 574, 575, 861) Diagnosis (female). Antennal clava with a weak constriction between C1 and C2 (Fig. 861); genal carina present; mesoscutellum (Fig. 574) with strong sculpture on median part and with a strong and complete median groove, lateral parts with strong reticulation, meshes elongate, submedian grooves ...
Hansson, Christer, Hanson, Paul E.
openaire   +2 more sources

Which Stitch? Replacing Anecdote with Evidence in Minor Hand Surgery

Plastic and Reconstructive Surgery, Global Open, 2019
Summary:. There is currently no consensus on the optimal suture type for palmar skin closure following open carpal tunnel release and trigger finger release.
Danielle H. Rochlin, MD, Clifford C. Sheckter, MD, Catherine M. Curtin, MD   +2 more
doaj   +1 more source

PELARGONIC ACID VANILYLLAMIDE (PAVA): RIOT CONTROL AGENT [PDF]

Military Medical Science Letters, 2011
Summary Riot control agents are highly potent sensory irritants of relatively low toxicity that produce dose and time-dependent acute site-specific toxicity. These compounds have been referred to as transient incapacitating agents or as lacrimators, and in common parlance they are known as "tear gases".
Jiří Patočka, Kamil Kuča
openaire   +1 more source

Anatomical and Neurochemical Correlates of Parental Verbal Abuse: A Combined MRS—Diffusion MRI Study

Frontiers in Human Neuroscience, 2019
Despite the critical impact of parental dialog on children who remain physically and psychologically dependent, most studies have focused on brain alterations in people exposed to moderate-to-high levels of emotional maltreatment with/without ...
Dohyun Kim, Jae Hyun Yoo, Young Woo Park, Minchul Kim, Dong Woo Shin, Bumseok Jeong   +5 more
doaj   +1 more source