Results 31 to 40 of about 1,183,998 (285)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Prioritisation of Pavement Maintenance based on Pavement Condition Index
Indian Journal of Science and Technology, 2015 The main objective of this study is to determine the Pavement Condition Index (PCI) through field data collection and analysis to prioritize the maintenance of pavements. Distress data such as cracks, patches, potholes, ruts etc. was collected along the identified sections of pavements selected based on severity of distress.
Bharath Boyapati, R. Prasanna Kumar
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Safety Impacts of Pavement Edge Drop-offs, 2006 [PDF]
, 2006 A vehicle may leave its travel lane for a number of reasons, such as driver error, poor surface conditions, or avoidance of a collision with another vehicle in the travel lane.
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
MILP-Based Approach for High-Altitude Region Pavement Maintenance Decision Optimization
Applied SciencesAffected by climatic factors (e.g., low temperature and intense ultraviolet radiation), high-altitude regions experience numerous pavement diseases, which compromise driving safety and negatively impact user travel experience.
Wu Bo +6 more
doaj +1 more source
Buildings, 2023 Asphalt pavement maintenance section classification is an important prerequisite for accurately determining asphalt pavement maintenance needs and formulating accurate maintenance plans. This paper introduces the three-dimensional (3D) ground-penetrating
Huimin Liu +5 more
doaj +1 more source