Results 41 to 50 of about 1,183,998 (285)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The Preventive Maintenance of Highway Based on Data Mining

MATEC Web of Conferences, 2017
Judging from the current situation of Chinese highway maintenance,only after there is highway distress would the staff have a repair, that results in the poor efficiency of highway maintenance.
Xiao Shunzhou, Nie Mingxin
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

BIM-Based Pavement Management Tool for Scheduling Urban Road Maintenance

Infrastructures, 2021
The latest advancements in road asphalt materials and construction technologies have increased the difficulty for engineers to select the appropriate pavement design solution with consideration of proper timing for maintenance planning. On the other hand,
Cristina Oreto, Luigi Massotti, Salvatore Antonio Biancardo, Rosa Veropalumbo, Nunzio Viscione, Francesca Russo   +5 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Local Roads Maintenance Workers’ Manual;TR-514, June 2006 [PDF]

, 2006
This manual describes best roadway maintenance practices for Iowa's local roads and streets, from the center line to shoulders, ditches, and drainage, with chapters on public relations, bridge maintenance, and snow and ice control. Each chapter contains

core  

Maintenance decision-making model of pavement based on reinforcement learning

Discover Applied Sciences
The pavement maintenance decision algorithm has emerged as a key research focus in the field of pavement management. Significant challenges remain in optimization algorithms designed to generate efficient maintenance plans.
Yajun Huang, Jin Wu, Pengchao You, Haiwei Sun, Xiang Fang   +4 more
doaj   +1 more source

Sustainable Pavement Maintenance and Rehabilitation Planning Using a Big-Data Based Microscopic Management Model

Infrastructures
The condition of pavement networks gradually deteriorates over years of use. Finding a suitable strategy to address this deterioration has become a key concern in pavement maintenance.
Hamed Maleki, Mohammad Bagher Fakhrzad, Fereidoon Moghadas Nejad, Hamzeh Zakeri, Akbar Danesh   +4 more
doaj   +1 more source

Neural networks in diagnostics of concrete airfield pavements

Roads and Bridges, 2022
Concrete airfield pavement maintenance encompasses many complex problems, which are difficult to identify using traditional diagnostic methods. Artificial neural networks may prove useful in understanding and solving of such problems.
Małgorzata Linek, Piotr Nita
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source