Results 21 to 30 of about 20,380 (169)
PAX6 and Congenital Eye Malformations [PDF]
Pediatric Research, 2003 The PAX6 gene is a paradigm for our understanding of the molecular genetics of mammalian eye development. Twelve years after its identification it is one of the most intensively studied genes, both in terms of its diverse and complex functions during oculogenesis and its role in an ever-increasing variety of human congenital eye malformations. The PAX6
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Downregulation of PAX6 by shRNA inhibits proliferation and cell cycle progression of human non-small cell lung cancer cell lines. [PDF]
PLoS ONE, 2014 The transcription factor PAX6 is primarily expressed in embryos. PAX6 is also expressed in several tumors and plays an oncogenic role. However, little is known about the role of PAX6 in lung cancer.The function of PAX6 in lung cancer cells was evaluated ...
Xiaoting Zhao +7 more
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Visual Acuity in Aniridia and WAGR Syndrome
Clinical Ophthalmology, 2023 Michael A Krause,1 Kelly L Trout,2 James D Lauderdale,3 Peter A Netland1 1Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA; 2International WAGR Syndrome Association, Montgomery Village, MD, USA; 3Department
Krause MA +3 more
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PLoS ONE, 2011 BackgroundAltered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6⁺/⁻ heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal epithelial ...
Richard L Mort +8 more
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Neural Development, 2009 Background The paired homeobox protein Pax6 is essential for proliferation and pluripotency of retinal progenitors. However, temporal changes in Pax6 protein expression associated with the generation of various retinal neurons have not been characterized
Yang Xian-Jie, Hsieh Yi-Wen
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BMC Cancer, 2018 Background The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highest-grade astrocytic glioma. The aim
Beate Hegge +2 more
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Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6(5a) isoform. [PDF]
PLoS ONE, 2014 Pax6 is a transcription factor important for early embryo development. It is expressed in several cancer cell lines and tumors. In glioblastoma, PAX6 has been shown to function as a tumor suppressor.
Siri Forsdahl +4 more
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Regulation of Pax6 by CTCF during induction of mouse ES cell differentiation. [PDF]
PLoS ONE, 2011 Pax6 plays an important role in embryonic cell (ES) differentiation during embryonic development. Expression of Pax6 undergoes from a low level to high levels following ES cell differentiation to neural stem cells, and then fades away in most of the ...
Jie Gao +4 more
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Intestinal Tumorigenicity of Mice Carrying Hemizygous Pax6, Pax6Sey-4H
Experimental Animals, 2007 The genotype-phenotype relationship in mice was examined experimentally using one of the small eye mutants, Pax6(Sey-4H), which deletes the chromosome 2 middle region, hemizygously. The genotyping indicated that the deleted region starts at a site 102.60 Mb from the centromere and has a length of 6.51 Mb, in which 12 known and 27 novel genes are ...
Yumiko, Nitta +5 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PAX6 (paired box 6), with data on DNA, on the protein encoded, and where the gene is implicated.
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