Results 31 to 40 of about 22,874 (232)
Diagnostics, 2020 Paired box 6 (PAX6) is a transcription factor that plays a critical role in tumor suppression, implying that the downregulation of PAX6 promotes tumor growth and invasiveness.
Koichiro Kimura +8 more
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PAX6 and Congenital Eye Malformations [PDF]
Pediatric Research, 2003 The PAX6 gene is a paradigm for our understanding of the molecular genetics of mammalian eye development. Twelve years after its identification it is one of the most intensively studied genes, both in terms of its diverse and complex functions during oculogenesis and its role in an ever-increasing variety of human congenital eye malformations. The PAX6
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BMC Cancer, 2018 Background The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highest-grade astrocytic glioma. The aim
Beate Hegge +2 more
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Developmental Biology, 2003 The Pax6 gene plays crucial roles in eye development and encodes a transcription factor containing both a paired domain and a homeodomain. During embryogenesis, Pax6 is expressed in restricted tissues under the direction of distinct cis-regulatory regions.
Aota, Shin-ichi +5 more
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PAX6 expression in the developing human eye [PDF]
British Journal of Ophthalmology, 1999 To investigate the changes in PAX6 expression in the developing human eye.Six developing human eyes from 6 to 22 weeks' gestation were evaluated. Frozen sections were immunohistochemically stained with monoclonal antibody to chick Pax6 (amino acids 1-223). To verify antibody specificity, western blot analysis was carried out using cell lysates from P19
Nishina, S. +6 more
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Pax6 and eye development in Arthropoda
Arthropod Structure & Development, 2006 The arthropod compound eye is one of the three main types of eyes observed in the animal kingdom. Comparison of the eyes seen in Insecta, Crustacea, Myriapoda and Chelicerata reveals considerable variation in terms of overall cell number, cell positioning, and photoreceptor rhabdomeres, yet, molecular data suggest there may be unexpected similarities ...
Callaerts, P +3 more
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Regulation of Pax6 by CTCF during induction of mouse ES cell differentiation. [PDF]
PLoS ONE, 2011 Pax6 plays an important role in embryonic cell (ES) differentiation during embryonic development. Expression of Pax6 undergoes from a low level to high levels following ES cell differentiation to neural stem cells, and then fades away in most of the ...
Jie Gao +4 more
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Rieger syndrome is associated with PAX6 deletion [PDF]
Acta Ophthalmologica Scandinavica, 2001 ABSTRACT. Purpose: Rieger syndrome is an autosomal dominant condition defined by anterior segment dysgenesis in combination with facial, dental, skeletal and umbilical abnormalities. To date Rieger syndrome has been associated with mutations in the PITX2 gene at chromosome 4q25 and a second locus has been found at chromosome 13q14.Methods: We describe ...
R, Riise +2 more
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Microarray investigation of the role of Pax6 at the PSPB using a novel tauGFP-Pax6 reporter mouse
, 2009 Pax6 encodes a highly conserved transcriptional regulator that is widely expressed during development of the eye, olfactory bulbs and central nervous system. Pax6-/- mice exhibit severe brain defects, lack eyes and nasal structures, and die at birth.
Catherine B. Carr
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PAX6 Expression Patterns in the Adult Human Limbal Stem Cell Niche
Cells, 2023 Paired box 6 (PAX6), a nuclear transcription factor, determines the fate of limbal epithelial progenitor cells (LEPC) and maintains epithelial cell identity. However, the expression of PAX6 in limbal niche cells, primarily mesenchymal stromal cells (LMSC)
Naresh Polisetti +2 more
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