Roles of TGFβ and FGF signals during growth and differentiation of mouse lens epithelial cell in vitro. [PDF]
, 2017 Transforming growth factor β (TGFβ) and fibroblast growth factor (FGF) signaling pathways play important roles in the proliferation and differentiation of lens epithelial cells (LECs) during development.
Gong, Xiaohua +5 more
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Neural Development, 2009 Background The paired homeobox protein Pax6 is essential for proliferation and pluripotency of retinal progenitors. However, temporal changes in Pax6 protein expression associated with the generation of various retinal neurons have not been characterized
Yang Xian-Jie, Hsieh Yi-Wen
doaj +1 more source
Diagnostics, 2020 Paired box 6 (PAX6) is a transcription factor that plays a critical role in tumor suppression, implying that the downregulation of PAX6 promotes tumor growth and invasiveness.
Koichiro Kimura +8 more
doaj +1 more source
Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]
, 2020 Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
core +1 more source
Susceptibility loci CNVs with incomplete penetrance accurate diagnosis with uncertain prognosis [PDF]
, 2019 Chromosomal microarray analysis (CMA) is the first-tier test for developmental delay, autism spectrum disorders, and congenital abnormalities in postnatal diagnosis and for ultrasound abnormalities in prenatal diagnosis.
Correia, Hildeberto +2 more
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BMC Cancer, 2018 Background The transcription factor PAX6 is expressed in various cancers. In anaplastic astrocytic glioma, PAX6 expression is inversely related to tumor grade, resulting in low PAX6 expression in Glioblastoma, the highest-grade astrocytic glioma. The aim
Beate Hegge +2 more
doaj +1 more source
Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. [PDF]
, 2014 Autism spectrum disorders (ASDs) are complex and heterogeneous developmental disabilities affecting an ever-increasing number of children worldwide. The diverse manifestations and complex, largely genetic aetiology of ASDs pose a major challenge to the ...
Adamopoulos, Iannis E +9 more
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Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. [PDF]
, 2018 The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events.
Hashimoto, Takao +3 more
core +1 more source
Regulation of Pax6 by CTCF during induction of mouse ES cell differentiation. [PDF]
PLoS ONE, 2011 Pax6 plays an important role in embryonic cell (ES) differentiation during embryonic development. Expression of Pax6 undergoes from a low level to high levels following ES cell differentiation to neural stem cells, and then fades away in most of the ...
Jie Gao +4 more
doaj +1 more source
Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3. [PDF]
, 2017 Mesoderm derived from human embryonic stem cells (hESCs) is a major source of the mesenchymal stem/stromal cells (MSCs) that can differentiate into osteoblasts and chondrocytes for tissue regeneration.
Aghaloo, Tara +6 more
core +2 more sources