Docosahexaenoic acid promotes photoreceptor differentiation without altering Crx expression [PDF]
, 2006 PURPOSE: The precise molecular cues required for photoreceptor development are still unknown. Pax6 and Crx are essential during early retinal development and for photoreceptor differentiation, respectively.
Garelli, Andres +2 more
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Competence, specification and commitment to an olfactory placode fate [PDF]
, 2008 The nasal placode shares a common origin with other sensory placodes within a pre-placodal domain at the cranial neural plate border. However, little is known about early events in nasal placode development as it segregates from prospective lens, neural ...
Bhattacharyya, Sujata +1 more
core +2 more sources
Excess caffeine exposure impairs eye development during chick embryogenesis [PDF]
, 2014 Caffeine has been an integral component of our diet and medicines for centuries. It is now known that over consumption of caffeine has detrimental effects on our health, and also disrupts normal foetal development in pregnant mothers.
Cheng, Xin +6 more
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BMC Research Notes, 2018 Objective The corneas of heterozygous Pax6 +/− mice develop abnormally and deteriorate further after birth but it is not known whether the postnatal deterioration is predetermined by abnormal development.
Natalie J. Dorà +6 more
doaj +1 more source
PAX6 and Congenital Eye Malformations [PDF]
Pediatric Research, 2003 The PAX6 gene is a paradigm for our understanding of the molecular genetics of mammalian eye development. Twelve years after its identification it is one of the most intensively studied genes, both in terms of its diverse and complex functions during oculogenesis and its role in an ever-increasing variety of human congenital eye malformations. The PAX6
openaire +2 more sources
Downregulation of PAX6 by shRNA inhibits proliferation and cell cycle progression of human non-small cell lung cancer cell lines. [PDF]
PLoS ONE, 2014 The transcription factor PAX6 is primarily expressed in embryos. PAX6 is also expressed in several tumors and plays an oncogenic role. However, little is known about the role of PAX6 in lung cancer.The function of PAX6 in lung cancer cells was evaluated ...
Xiaoting Zhao +7 more
doaj +1 more source
Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia [PDF]
, 2007 With the exception of astroglia-like cells in the neurogenic niches of the telencephalic subependymal or hippocampal subgranular zone, astroglia in all other regions of the adult mouse brain do not normally generate neurons.
Berninger, Benedikt +6 more
core +1 more source
Visual Acuity in Aniridia and WAGR Syndrome
Clinical Ophthalmology, 2023 Michael A Krause,1 Kelly L Trout,2 James D Lauderdale,3 Peter A Netland1 1Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA; 2International WAGR Syndrome Association, Montgomery Village, MD, USA; 3Department
Krause MA +3 more
doaj
PLoS ONE, 2011 BackgroundAltered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6⁺/⁻ heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal epithelial ...
Richard L Mort +8 more
doaj +1 more source
Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6(5a) isoform. [PDF]
PLoS ONE, 2014 Pax6 is a transcription factor important for early embryo development. It is expressed in several cancer cell lines and tumors. In glioblastoma, PAX6 has been shown to function as a tumor suppressor.
Siri Forsdahl +4 more
doaj +1 more source