Results 241 to 250 of about 2,102,666 (322)
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
結風 虹のあと My Life : From Rice PB to LTD 私の人生 : 米プロテインボディ研究から話し合い学習まで
雅広 小川
openalex +1 more source
Verbos de trajetória do PB: uma descrição sintático-semântica
Rosimeire Corrêa, Márcia Cançado
openalex +2 more sources
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Airborne lead arsenate chloride (mimetite) microcrystals in ambient air as a potential health hazard. [PDF]
Jabłońska M +3 more
europepmc +1 more source
Measurement of $_\Lambda^3$H production in Pb–Pb collisions at $\sqrt{s_{NN}}$ = 5.02 TeV
Shreyasi Acharya +99 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Hypertension Increases Susceptibility to Lead-Induced Microglial Polarization via ANT1-Mediated Mitochondrial DNA/cGAS/STING Signaling. [PDF]
Zhao Y +8 more
europepmc +1 more source

