Results 251 to 260 of about 849,713 (290)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Validation and reliability of the Italian versions of the Food Allergy Quality of Life -Parental Burden (FAQL-PB) and -Parent Form 10 (FAQLQ-PF10) Questionnaires. [PDF]

Pediatr Allergy Immunol
Comberiati P, Barni S, Miccoli M, DunnGalvin A, Mori F, Sarti L, Poli A, Munblit D, D'Auria E, Fleischer D, Peroni DG, Greenhawt M.   +11 more
europepmc   +1 more source

Environmental Toxic Elements and Atherosclerotic Disease: The Epigenetic Connection. [PDF]

Life (Basel)
Simonini L, Gorini F, Palazzo M, Minichilli F, Borghini A.   +4 more
europepmc   +1 more source

Narrowband Emitting Tin Dion-Jacobson Perovskites through Systematic Spacer Cation Design to Suppress Metal Lone-Pair Anisotropy. [PDF]

J Am Chem Soc
Forlano KM, Xie J, Triggs CT, Román-Matías J, Kohler DD, Canestra F, Femoni C, Lafayette DP, Guzei IA, Cortecchia D, Wright JC, Yan Y, Jin S.   +12 more
europepmc   +1 more source

Systematic versus perilesional sampling in transperineal MRI-fusion biopsy: is perilesional sampling ready for prime time? A high-volume center analysis. [PDF]

World J Surg Oncol
Seebold A, Büttner T, Ellinger J, Kristiansen G, Bernhardt M, Isaak A, Hoffmann C, Luetkens JA, Ritter M, Krausewitz P.   +9 more
europepmc   +1 more source

Cumulative and Interactive Effects of Heavy Metal Mixtures Across Neurodegenerative Diseases: A Comparative Review of Alzheimer, Parkinson, Amyotrophic Lateral Sclerosis and Multiple Sclerosis. [PDF]

J Xenobiot
Mitu I, Caba IC, Macovei I.
europepmc   +1 more source