Results 251 to 260 of about 154,598 (309)

Effects of the Hypomethylating Agent Guadecitabine on Peripheral Blood Mononuclear Cell Methylomes and Immune Cell Populations in Small-Cell Lung Cancer Patients. [PDF]

Pharmaceuticals (Basel)
Farid EA, Zhang S, Fu Z, Coon CM, Matei D, Jalal SI, Nephew KP.   +6 more
europepmc   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Pervasive enhanced transcription in inflammatory breast cancer tumors and PBMCs impacts RNA splicing and intronic RNAs in plasma. [PDF]

Sci Adv
Wylie D, Wang X, Yao J, Xu H, Ferrick-Kiddie EA, Iwase T, Krishnamurthy S, Ueno NT, Lambowitz AM.   +8 more
europepmc   +1 more source

A Droplet‐Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients’ Blood Plasma Samples

Small, EarlyView.
This study presents a droplet‐microarray platform integrated with a DNase I‐assisted MoS2 FRET aptasensor for multiplexed profiling of breast cancer subtypes’ exosomes from patients’ plasma. By targeting HER2, MUC1, and CD44, the system enables sensitive detection and accurate discrimination of luminal A, HER2‐positive, and triple‐negative subtypes ...
Yi Liu, Ruolin Zhang, Jialei Song, Meng Xiao, Yue Meng, Zhiyang Li, Jingyu Shi, Yunyan Tai, Bing Gu, Mo Yang   +9 more
wiley   +1 more source

Targeting pyruvate kinase M2 (PKM2) reduces T cell pathogenicity in multiple sclerosis. [PDF]

EBioMedicine
Ellmeier E, Schnabl A, Meissel J, Stracke A, Rittchen S, Stöger L, Passegger CA, Schwarzl L, Tafrali C, Demjaha R, Martinez-Serrat M, Kaiser T, Zeiler LC, Seifried K, Topler A, Klemen I, Heschl B, Damulina A, Runtsch MC, Fessler J, Hofer E, Khalil M, Angiari S.   +22 more
europepmc   +1 more source

A Label‐Free Ultraviolet Photoacoustic Microscopy Enables Nuclear Imaging and Toxicity Assessment in an Intact Brain Organoid

Small, EarlyView.
Ultraviolet photoacoustic microscopy enables label‐free visualization of nuclear morphology in intact human brain organoids. By exploiting endogenous nucleic acid absorption at 266 nm, this approach resolves individual nuclei without staining or sectioning.
Hyunjun Kye, Won Jong Yu, Lihong V. Wang, Jeesu Kim, Jong‐Chan Park, Byullee Park   +5 more
wiley   +1 more source

SM03, a non-depleting anti-CD22 antibody, modulates B cell activation and immune crosstalk to attenuate autoimmunity. [PDF]

J Transl Autoimmun
Wong KL, Cheng LH, Chung CL, Ng PL, Nawabjan SA, Sethuraman MIG, Luk KK, Tsoi WT, Chow BKC, Leung SO.   +9 more
europepmc   +1 more source

RNA‐DNA Fusomer Fibers With Customizable Physicochemical, Mechanical, and Biological Properties for Next‐Generation Therapeutics

Small, EarlyView.
ABSTRACT We introduce RNA‐DNA fusomers, a new class of chemically synthesized oligonucleotides that combine the versatile properties of RNA and DNA within a single sequence and self‐assemble into higher‐order functional structures via a simple one‐pot annealing reaction.
Yasmine Radwan, Laura P. Rebolledo, Yelixza I. Avila, Elizabeth Skelly, Lauren Rackley, Julio Navas Hernandez, Renata de Freitas Saito, Laxmi K. Pandey, Hemani Chhabra, Alexander J. Lushnikov, Tatiane Katsue Furuya, Ana Luiza Lomba, Da Shi, Edward Cedrone, Ian Marriott, Morgan R. Chandler, Meni Wanunu, Aleksei Aksimentiev, Alexey V. Krasnoslobodtsev, Roger Chammas, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Modelling inflammatory endothelial dysfunction: a human in vitro platform for translational research. [PDF]

Front Bioeng Biotechnol
Cheremkhina M, Babendreyer A, Neullens CT, Krapp S, Pabst A, Ohl K, Ruetten S, Ludwig A, Cornelissen CG, Jockenhoevel S, Tenbrock K, Thiebes AL.   +11 more
europepmc   +1 more source