Results 231 to 240 of about 16,022 (277)

Advancing rare disease therapeutics through digital twins: Opportunities in drug development and precision dosing. [PDF]

Comput Struct Biotechnol J
Dette CMU, Alberg V, Rüdesheim S, Selzer D, Marok FZ, Bragazzi NL, Fuhr LM, Brunak S, Pearson ER, Zahn T, Kiritsi D, Schwab M, Lehr T.   +12 more
europepmc   +1 more source

A Physiologically Based Pharmacokinetic Model for the Prediction of Plasma and Bone Tissue Exposure after Prophylactic Administration of Ampicillin/Sulbactam in Patients with Osteonecrosis of the Jaw. [PDF]

Clin Pharmacokinet
Stapf M, Straub A, Steinacker V, Hartmann S, Scherf-Clavel O.   +4 more
europepmc   +1 more source

Optimizing Clinical Dosing Strategies to Mitigate Corneal Toxicity: Ocular PBPK Model-Based Evaluation of the Extent and Rate of Therapeutic Protein Distribution in the Human Cornea

Annie Lumen, Leticia Arrington, Di Zhou, Vijay Upreti   +3 more
openalex   +1 more source

Emerging perspectives on leveraging physiologically based biopharmaceutics modeling (PBBM) for BCS class III biowaivers: A webinar summary. [PDF]

J Pharm Sci
Fang L, Veerasingham S, Xu Y, Garcia-Arieta A, Kollipara S, Kanagasabapathy Y, Ahmed T, Martins FS, Suarez-Sharp S.   +8 more
europepmc   +1 more source

Cardiotoxicity of different 5-HT3 receptor antagonists analyzed using the FAERS database and pharmacokinetic study. [PDF]

Sci Rep
Cai Y, Luo S, Lin S, Huang X, Wang X, Yang L, Xu X, Weng X.   +7 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling and Simulations in Lieu of Clinical Pharmacology Studies to Support the New Drug Application of Asciminib. [PDF]

Pharmaceutics
Loisios-Konstantinidis I, Huth F, Hoch M, Einolf HJ.   +3 more
europepmc   +1 more source

Une Approche quantitative de l'exposition fœtale au plomb : développement d'un modèle pharmacocinétique basé sur la physiologie de la grossesse (p-PBPK) et application aux données de biosurveillance

Yourdasmine Ali Daoud
openalex   +1 more source

PBPK in liver cirrhosis population

, 2019
openaire   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Physiologically based pharmacokinetics (PBPK)

Drug Metabolism Reviews, 2009
Allometric scaling is widely used to predict human pharmacokinetic parameters from preclinical species, and many different approaches have been proposed over the years to improve its predictive performance. Nevertheless, prediction errors are commonly observed in the practical application of simple allometry, for example, in cases where the hepatic ...
Pascal, Espié, Dominique, Tytgat, Maria-Laura, Sargentini-Maier, Italo, Poggesi, Jean-Baptiste, Watelet   +4 more
openaire   +2 more sources