Results 141 to 150 of about 3,220 (195)

Quantitative Evaluation of Model‐Informed Drug Development Implementation in China's Approved Innovative Drugs: From Policy to Practice (2018–2024)

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Model‐informed drug development (MIDD) has emerged as a cornerstone paradigm in global pharmaceutical innovation. Historically underutilized in China, MIDD methodologies gained momentum following the National Medical Products Administration's (NMPA) 2020 release of the Model‐Informed Drug Development Technical Guideline, which was subsequently
Jian Li, Zhenlei Wang, Chunmin Wei, Ruirui He, Qingyu Yao   +4 more
wiley   +1 more source

Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Efavirenz's effects on cytochrome P450 2C9 (CYP2C9) activity have not been formally characterized in vivo. We conducted the first clinical drug–drug interaction (DDI) study to test the effect of chronic efavirenz dosing on CYP2C9 activity, using tolbutamide as a selective probe.
Jason D. Kim, Ingrid F. Metzger, Jessica Bo Li Lu, Todd C. Skaar, Zeruesenay Desta   +4 more
wiley   +1 more source

Artificial intelligence coupled to pharmacometrics modelling to tailor malaria and tuberculosis treatment in Africa

Nature Communications
Africa’s vast genetic diversity poses challenges for optimising drug treatments in the continent, which is exacerbated by the fact that drug discovery and development efforts have historically been performed outside Africa.
Gemma Turon, Mwila Mulubwa, Anna Montaner, Mathew Njoroge, Kelly Chibale, Miquel Duran-Frigola   +5 more
doaj   +1 more source

Modeling and Simulation of Triclosan Kinetics and Distribution in Humans Using a PBPK Model [PDF]

, 2015
Andreassen, Monica, Dirven, Hubert, Husøy, Trine, Lie, Bernt, Maharjan, Samee, Sharma, Roshan   +5 more
core   +4 more sources

Dicloxacillin and Flucloxacillin Inhibit Hepatic Uptake Transporters—In Vitro Investigations and Physiologically Based Pharmacokinetic Modeling

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Dicloxacillin and flucloxacillin are β‐lactamase‐resistant penicillin antibiotics that have been in clinical use for over 50 years. While both antibiotics are known to induce cytochrome P450 enzymes, there is limited information available regarding their interactions with drug transporters.
Noora Sjöstedt, Ogochukwu U. Amaeze, Jeroen J. M. W. van den Heuvel, Tore B. Stage, Jan B. Koenderink, Nina Isoherranen, Heidi Kidron, Erkka Järvinen   +7 more
wiley   +1 more source

Human PBPK Modeling

This deliverable will report the final development of the human PBPK models developed within ...
openaire   +1 more source

Highlight report: Interspecies extrapolation by physiologically based pharmacokinetic modeling [PDF]

, 2015
Widera, Agata
core   +1 more source

Editorial: Exploring Maternal-Fetal Pharmacology Through PBPK Modeling Approaches

Frontiers in Pediatrics, 2022
André Dallmann, John N. van den Anker, John N. van den Anker   +2 more
openaire   +3 more sources

Sound understanding of environmental, health and safety, clinical, and market aspects is imperative to clinical translation of nanomedicines [PDF]

, 2017
Boisseau, Patrick, Herrmann, Inge K, Liptrott, Neill J, Owen, Andrew, Rosslein, Matthias, Wick, Peter   +5 more
core   +1 more source

Possibilities and limitations of intravital imaging [PDF]

, 2016
Reham, Hassan
core   +1 more source