Results 151 to 160 of about 3,220 (195)

Optimisation of Intramuscular Sustained Release-Nano-Formulations Using In Silico Modelling [PDF]

, 2014
Back, D, Owen, A, Rajoli, RKR, Rannard, S, Siccardi, M   +4 more
core  

Simulation of propofol anaesthesia for intracranial decompression using brain hypothermia treatment [PDF]

Lu Gaohua, Hidenori Kimura, AL Georgiadis, KH Polderman, S Himmelseher, N Hayashi, FL Roberts, KH Polderman, K Leslie, RN Upton, DG Levitt, L Gaohua, L Gaohua, K McKeage, T Matsukawa, O Engdahl, T Ouchi, BM Weaver, KW Park   +18 more
core   +1 more source

Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models [PDF]

, 2007
Michaela Vossen, Michael Sevestre, Christoph Niederalt, In-Jin Jang, Stefan Willmann, Andrea N Edginton   +5 more
core   +1 more source

Issue Information

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
wiley   +1 more source

Development of physiologically based pharmacokinetic models for the bioaccumulation of persistent organic pollutants in marine mammals [PDF]

, 2013
Weijs, L
core  

Combining ‘Bottom-Up’ and ‘Top-Down’ Methods to Assess Ethnic Difference in Clearance: Bitopertin as an Example [PDF]

core   +1 more source

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Postnatal Growth Considerations for PBPK Modeling

Journal of Toxicology and Environmental Health, Part A, 2007
A physiologically based pharmacokinetic (PBPK) model and Windows-based program (called PostNatal) was developed that focuses on postnatal growth, from birth through adulthood, using appropriate growth curves for each species and gender. Postnatal growth algorithms relating organs/tissues weights with total body weight for male and female humans, dogs ...
Richard H, Luecke, Bruce A, Pearce, Walter D, Wosilait, William, Slikker, John F, Young   +4 more
openaire   +2 more sources

PHYSIOLOGICAL “CONSTANTS” FOR PBPK MODELS FOR PREGNANCY

Journal of Toxicology and Environmental Health, 1997
Physiologically based pharmacokinetic (PBPK) models for pregnancy are inherently more complex than conventional PBPK models due to the growth of the maternal and embryo/fetal tissues. Physiological parameters such as compartmental volumes or flow rates are relatively constant at any particular time during gestation when an acute experiment might be ...
J F, Young, W S, Branham, D M, Sheehan, M E, Baker, W D, Wosilait, R H, Luecke   +5 more
openaire   +2 more sources

PBPK and Toxicokinetic Modeling

2022
Presentation to OpenTox 2022 on Sept. 16, 2022 Science Inventory, CCTE products: https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&TIMSType=&TIMSSubTypeID=&epaNumber=&ombCat=Any&dateBeginPublishedPresented=07/01/2017&dateEndPublishedPresented=&dateBeginUpdated=& ...
openaire   +1 more source

QSARs for PBPK modelling of environmental contaminants

SAR and QSAR in Environmental Research, 2011
Physiologically-based pharmacokinetic (PBPK) models are increasingly finding use in risk assessment applications of data-rich compounds. However, it is a challenge to determine the chemical-specific parameters for these models, particularly in time- and resource-limiting situations.
T, Peyret, K, Krishnan
openaire   +2 more sources