Results 51 to 60 of about 3,220 (195)

Physiologically-based pharmacokinetic simulations in pharmacotherapy: selection of the optimal administration route for exogenous melatonin

ADMET and DMPK, 2019
The benefits of melatonin on human body are drawing increasing attention from several researchers in different fields. While its role as cure for sleep disturbances (e.g., jet lag, insomnia) is well documented and established, new functions in ...
Adriana Savoca, Davide Manca
doaj   +1 more source

Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib

Frontiers in Pharmacology, 2022
Aim: It has been found that the co-administration of nifedipine with apatinib could cause exposure changes of nifedipine in vivo. But, whether this pharmacokinetic drug-drug interaction (DDI) between nifedipine and apatinib could enhance the ...
Hongrui Liu, Yiqun Yu, Lu Liu, Chunyan Wang, Nan Guo, Xiaojuan Wang, Xiaoqiang Xiang, Xiaoqiang Xiang, Bing Han   +8 more
doaj   +1 more source

Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies [PDF]

, 2015
Introduction: The pharmacokinetic properties of anti-infective drugs are a determinant part of treatment success. Pathogen replication is inhibited if adequate drug levels are achieved in target sites, whereas excessive drug concentrations linked to ...
Marzolini, C, Moss, DM, Rajoli, RK, Siccardi, M   +3 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Mathematical Modeling of Local Drug Delivery in the Oral Cavity: From Release Kinetics to Mini-PBPK and Local PK/PD with Applications to Periodontal Therapies

Pharmaceutics
Background/Objectives: Mathematical modelling provides a quantitative way to describe the fate and action of drugs in the oral cavity, where transport processes are shaped by salivary flow, pellicle formation, biofilm structure and the wash-out effect of
Rafał Rakoczy, Monika Machoy-Rakoczy, Izabela Gutowska   +2 more
doaj   +1 more source

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.

Frontiers in Pharmacology, 2014
This study aimed to demonstrate the added value of integrating prior in vitro data and knowledge-rich physiologically based pharmacokinetic (PBPK) models with pharmacodynamics (PD) models.
Manoranjenni eChetty, Rachel eRose, Khaled eAbduljalil, Nikunjkumar ePatel, Gaohua eLu, Theresa eCain, Masoud eJamei, Amin eRostami-Hodjegan, Amin eRostami-Hodjegan   +8 more
doaj   +1 more source

Human Food Safety Implications of Variation in Food Animal Drug Metabolism [PDF]

, 2016
Citation: Lin, Z., Vahl, C. I., & Riviere, J. E. (2016). Human Food Safety Implications of Variation in Food Animal Drug Metabolism. Scientific Reports, 6.
Lin, Zhoumeng, Riviere, Jim E., Vahl, Christopher I.   +2 more
core   +1 more source

Prospects and limitations of physiologically-based pharmacokinetic modelling for cross-species extrapolation

SVU-International Journal of Veterinary Sciences, 2019
The transition from experimental findings in animal models to clinical applications in human patients is a key challenge in pharmacology and toxicology.
Lars Kuepfer
doaj   +1 more source

Introduction and Review of Modeling and Predicting Toxicity of Chemical Substances Based on Physiologically-Based Pharmacokinetic Models Using Computer Software [PDF]

تحقیقات نظام سلامت, 2023
Nowadays, the application of kinetic models based on physiology in modelling and predicting the level of toxicity of chemical substances is developing rapidly. The data extracted from these models are being used in environmental risk assessment. They are
Sara Karimi-Zeverdegani, Seyed Mahdi Mousavi, Mojtaba Nakhaeipour, Hossein Ebrahimi   +3 more
doaj  

Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents

Pharmaceutics, 2021
Acid reducing agents (ARAs) reduce the dissolution rate of weakly basic drugs in the stomach potentially leading to lower bioavailability. Formulating the API as a rapidly dissolving salt is one strategy employed to reduce the impact of ARAs on ...
Siri Kalyan Chirumamilla, Venkatesh Teja Banala, Masoud Jamei, David B. Turner   +3 more
doaj   +1 more source