Results 101 to 110 of about 1,072,724 (364)

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension. [PDF]

, 2017
Objective:Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in ...
Collak, Filiz Kisaayak, Demir, Ummuhan, Kurum, Esra, Ozkanli, Seyma, Zerk, Pinar Engin   +4 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Local PCA Shows How the Effect of Population Structure Differs Along the Genome

Genetics, 2016
Principal component analysis (PCA) is often used to describe overall population structure—patterns of relatedness arising from past demographic history—among a set of genomes. Here, Li and Ralph describe how the patterns uncovered by....
Han Li, Peter L. Ralph
semanticscholar   +1 more source

PCA-based lung motion model

, 2010
Organ motion induced by respiration may cause clinically significant targeting errors and greatly degrade the effectiveness of conformal radiotherapy. It is therefore crucial to be able to model respiratory motion accurately.
Arslan S, Daniel A Low, Deshan Yang, Duda R O, Heinrich M P, James Lamb, John H Lewis, Jolliffe I T, Kakar M, Loeve M, McCall K C, Murphy M J, Murphy M J Jalden J Isaksson M, Neicu T, Pock T, Ren Q, Ruan D, Ruan D, Ruijiang Li, Sara Wuenschel, Sharp G C, Sohn M, Steve B Jiang, Tianyu Zhao, Vedam S S, Weifeng Liu, Wu H, Xun Jia, Yang X Klette R   +28 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pilot development of innovation scales for beverage manufacturing companies in a developing country

Cogent Business & Management, 2017
Innovation can enhance economic success for companies and countries alike. This study identified innovation drivers for beverage manufacturing companies in the developing nation, Trinidad and Tobago (T&T).
Marcia Nathai-Balkissoon, Chris Maharaj, Rafael Guerrero, Rydell Mahabir, Isaac Dialsingh   +4 more
doaj   +1 more source

Fair principal component analysis (PCA): minorization-maximization algorithms for Fair PCA, Fair Robust PCA and Fair Sparse PCA

, 2023
In this paper we propose a new iterative algorithm to solve the fair PCA (FPCA) problem. We start with the max-min fair PCA formulation originally proposed in [1] and derive a simple and efficient iterative algorithm which is based on the minorization-maximization (MM) approach.
Babu, Prabhu, Stoica, Petre
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Forest Fire Hazard Forecasting Based on Google Earth Engine Open Satellite Data

Кібернетика та комп'ютерні технології
Introduction. Forest fires cause significant damage to both the natural fund and the national economy. In recent years, their harmful influence has increased due to global warming, and in Ukraine also due to the armed conflict.
Ivan Denkov, Yevhen Nazarenko
doaj   +1 more source