Results 71 to 80 of about 387,650 (261)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Le fait du prince comme cause d’admission au régime de force majeure en droit minier congolais : notion, portée et implications [PDF]

Mouvements et Enjeux Sociaux
La succession d’évènements tragiques au cours des XX et XXIe siècles a mis en évidence l’importance de la gestion des risques avec notamment des risques industriels, financiers, sociétaux (les soulèvements), sanitaires (pandémie de covid-19), ou encore ...
Patrick BONDONGA LESAMBO , Kevin ESHIMATA NGIMBI   +1 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Identification of Abnormal data in online dissolved gas monitoring in oil based on PCA and Fast-MCD

Zhejiang dianli
To detect the operational status of transformers by online monitoring of dissolved gases in oil is critical for ensuring its stable operation. However， faults in monitoring devices can result in abnormal data， severely impacting the effect of online ...
WANG Ziling, WANG Ke, CHAI Weijian, LI Yexin, ZOU Guoping, AN Siguang   +5 more
doaj   +1 more source

Tocochromanols and fatty acid composition in flax (Linum usitatissimum L.) accessions

Acta Societatis Botanicorum Poloniae, 2019
Flax, Linum usitatissimum, cultivars are grown throughout the world. Flax oil is a dietary source of polyunsaturated fatty acids, vitamin E, as well as phospholipids, sterols, and phenolic acids.
Agnieszka Trela, Grażyna Silska, Marek Chyc, Dariusz Latowski, Jerzy Kruk, Renata Szymańska   +5 more
doaj   +1 more source

Effects of anthropogenic activities on nutrient parameters in the North Eastern Mediterranean Sea (Bay of Sığacık/Aegean Sea)

Oceanological and Hydrobiological Studies, 2022
This study aims to examine the physicochemical parameters of seawater (temperature, pH, salinity, dissolved oxygen, suspended particulate matter, ammonium-nitrogen, nitrite-nitrogen, nitrate-nitrogen, and phosphate-phosphorus, burnable organic matter in ...
Çulha Saniye Türk, Karaduman Fatma Rabia, Gündoğdu Ayşe, Barış Kamil Emre   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Yield and vegetation index of different maize varieties and nitrogen doses under normal irrigation

Open Agriculture
Nitrogen is essential nutrient that supports the growth and yield of corn. The correct dose of nitrogen fertilization is one of the keys to increasing corn productivity by its yield potential.
Padjung Rusnadi, Farid Muh., Musa Yunus, Nasaruddin Nasaruddin, Nurfaida Nurfaida, Anshori Muhammad Fuad, Achmad Mahmud, Arinong Abdul Rahman, Amier Nirwansyah   +8 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source