Results 61 to 70 of about 386,310 (261)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Identification of Abnormal data in online dissolved gas monitoring in oil based on PCA and Fast-MCD
Zhejiang dianliTo detect the operational status of transformers by online monitoring of dissolved gases in oil is critical for ensuring its stable operation. However， faults in monitoring devices can result in abnormal data， severely impacting the effect of online ...
WANG Ziling +5 more
doaj +1 more source
Tocochromanols and fatty acid composition in flax (Linum usitatissimum L.) accessions
Acta Societatis Botanicorum Poloniae, 2019 Flax, Linum usitatissimum, cultivars are grown throughout the world. Flax oil is a dietary source of polyunsaturated fatty acids, vitamin E, as well as phospholipids, sterols, and phenolic acids.
Agnieszka Trela +5 more
doaj +1 more source
Oceanological and Hydrobiological Studies, 2022 This study aims to examine the physicochemical parameters of seawater (temperature, pH, salinity, dissolved oxygen, suspended particulate matter, ammonium-nitrogen, nitrite-nitrogen, nitrate-nitrogen, and phosphate-phosphorus, burnable organic matter in ...
Çulha Saniye Türk +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Yield and vegetation index of different maize varieties and nitrogen doses under normal irrigation
Open AgricultureNitrogen is essential nutrient that supports the growth and yield of corn. The correct dose of nitrogen fertilization is one of the keys to increasing corn productivity by its yield potential.
Padjung Rusnadi +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Electronic Journal of Plant Breeding, 2016 White grained finger millet genotypes has become a thrust area in finger millet breeding due to increased demand of nonglutinous food products and lesser acceptability of brown grained finger millet.
Salej Sood +4 more
doaj +1 more source