Results 181 to 190 of about 578,033 (291)

Unravelling therapeutic resistance: role of cancer stem cell and microRNA in metastatic prostate cancer. [PDF]

Front Mol Biosci
Moondra H, Choudhary GR, Ahirwar DK, Banerjee M, Shukla SK, Shukla KK.   +5 more
europepmc   +1 more source

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Structure of recombinant Thermoascus aurantiacus xylanase TaXyn10 with an authentic N-terminal pyroglutamate. [PDF]

Acta Crystallogr F Struct Biol Commun
Mijatovic J, Mueller U, Weiss MS, Lennartz F.   +3 more
europepmc   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Burden of Treatment-Induced Vasomotor Symptoms in Men With Prostate Cancer on Androgen-Deprivation Therapy: A Systematic Literature Review. [PDF]

Prostate Cancer
Ajmera M, Lou KJ, Ng S, Helbing M.
europepmc   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Autoencoders for unsupervised analysis of rat myeloarchitecture. [PDF]

Brain Struct Funct
Estela M, Salo RA, San Martín Molina I, Narvaez O, Kolehmainen V, Tohka J, Sierra A.   +6 more
europepmc   +1 more source

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

Advanced Science, EarlyView.
ABSTRACT Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...
Xiaoyan Tang, Zhe Li, Yuning Lu, Miao Ma, Zijian Mo, Jiajun Ke, Xinyu Luan, Tiangang Luan, Junqiu Zhai   +8 more
wiley   +1 more source

Urinary Trace Element Concentrations in Congolese Patients With Prostate Cancer: A Case-Control Study. [PDF]

Prostate Cancer
Mbey PM, Mukuku O, Saleh CU, Manika MM, Diangienda PDK, Moningo DM.   +5 more
europepmc   +1 more source

Characterization of metabolic alteration patterns in patients with glioma using Scaled Subprofile Modeling – PCA

reservedIl modello di profilo scalato (SSM) è un algoritmo multivariato basato su PCA che identifica le principali fonti di variazione nei dati delle immagini cerebrali di pazienti e gruppi di controllo, mentre respinge componenti di minore importanza ...
FAJRI, JONES
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