Results 211 to 220 of about 527,772 (339)
Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang+9 more
wiley +1 more source
Prostate cancer incidence and mortality among immigrants in Finland between 2000 and 2017 - a register-based cohort study. [PDF]
Mustonen KM+3 more
europepmc +1 more source
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He+16 more
wiley +1 more source
Diagnostic value of CD138 and GATA3 in benign prostatic hyperplasia and prostate cancer. [PDF]
Hu Y+5 more
europepmc +1 more source
A PCA‐based modelling technique for predicting environmental suitability for organisms from presence records [PDF]
Mark P. Robertson+2 more
openalex +1 more source
IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu+10 more
wiley +1 more source
The role and mechanisms of exosome microRNA in regulating metastasis within the tumor microenvironment of prostate cancer. [PDF]
Song Y, Wang Q, Liang B, Zou S.
europepmc +1 more source